Exodus‐2 is a CC chemokine that signals through the CCR7 receptor. It is expressed in lymphatic endothelial cells, the spleen and appendix. Exodus‐2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus‐2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant Human Exodus‐2 (CCL21) is a 12.2 kDa protein containing 111 amino acid residues.
Expressed using different clones, Cat# 300-35 and Cat# 300-35A differ from one another at amino acid positions 100 and 101, where the amino acids arginine (R) and lysine (K) are transposed.
SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCK RTERSQTPKG P
≥ 98% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to chemoattract human activated T cells cultured in the presence of IL-2.
Calculated Molecular Weight: