Recombinant Human Fractalkine (CX3CL1) 0 评论Submit a Review 产品详情 产品编号: 300-31 产品描述: Fractalkine is a CX3CL chemokine that signals through the CX3CR1 receptor. Fractalkine has been shown to chemoattract monocytes, microglia cells and NK cells. Fractalkine is, at this time, the only CXC3C chemokine that contains three amino acid residues between the first and second cysteine residues of the chemokine domain. The Fractalkine gene encodes for a 397 amino acid precursor protein containing a 24 amino acid signal sequence, a chemokine domain, and a "mucin-like stalk" sequence, which is followed by the transmembrane domain containing approximately 20 amino acids, and a C-terminal cytoplasmic domain. The extracellular chemokine domain contains 76 amino acid residues, including the four conserved cysteine residues found in other chemokines. Recombinant Human Fractalkine is an 8.5 kDa protein containing 76 amino acid residues, including the four conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: Neurotactin, CX3CL1, FKN AA Sequence: QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human T cells using a concentration range of 5.0-10.0 ng/ml. Calculated Molecular Weight: 8.5 kDa Accession Number: P78423 Gene ID: 6376 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Human + Virus, Monkey, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 艾滋病/HIV 血管生成/心血管 细胞凋亡 癌症 化学趋化 免疫系统 炎症 神经生物学 创伤修复 product.subtitle.recentcitations 第一作者 Park, J 标题 Multi-Omics-Based Autophagy-Related Untypical Subtypes in Patients with Cerebral Amyloid Pathology. 文献引用 Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(23) pge2201212 PubMed Id 35694866 第一作者 Magusali, N 标题 A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. 文献引用 Brain : A Journal Of Neurology; 144(12) pg3727-3741 PubMed Id 34619763 第一作者 De Groof, T W 标题 Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies 文献引用 Nature Communications; 12(1) pg4357 PubMed Id 34272386