Recombinant Human gAcrp30/Adipolean 0 评论Submit a Review 产品详情 产品编号: 450-21 产品描述: gAcrp30 is a naturally occurring globular protein obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, gAcrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and named AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver. Recombinant Human gAcrp30/Adipolean is a 16.6 kDa protein consisting of 145 amino acid residues. Source: E.coli Synonyms: APM-1, Adipolean (human), gad, globular domain of Acrp30 AA Sequence: MKGEPGEGAY VYRSAFSVGL ETYVTIPNMP IRFTKIFYNQ QNHYDGSTGK FHCNIPGLYY FAYHITVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the proliferation of murine M1 cells. The expected ED50 for this effect is 1.0-3.0 μg/ml. Calculated Molecular Weight: 16.6 kDa Accession Number: Q15848 Gene ID: 9370 Endotoxin: Endotoxin level is < 0.2 ng/ug of protein (< 2 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 糖尿病/体重调节 product.subtitle.recentcitations 第一作者 Dubessy, A 标题 Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS. 文献引用 Glia; 67(12) pg2248-2263 PubMed Id 31328333 第一作者 Tilija Pun, N 标题 Critical role of tristetraprolin and AU-rich element RNA-binding protein 1 in the suppression of cancer cell growth by globular adiponectin. 文献引用 FEBS Open Bio; 8(12) pg1964-1976 PubMed Id 30524947 第一作者 Tishinsky, J M 标题 Fish oil prevents high-saturated fat diet-induced impairments in adiponectin and insulin response in rodent soleus muscle. 文献引用 American journal of physiology. Regulatory, integrative and comparative physiology; 302(5) pgR598-605 PubMed Id 22204953