Animal-Free Recombinant Human IFN-γ 0 评论Submit a Review 产品详情 产品编号: AF-300-02 产品描述: IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant Human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Immune Interferon, type II interferon, T cell interferon, MAF AA Sequence: MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 16.8 kDa Accession Number: P01579.1 Gene ID: 3458 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Fish + Virus, Human, Human + Bacteria, Mandarin Fish, Monkey, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 艾滋病/HIV 血管生成/心血管 癌症 糖尿病/体重调节 免疫系统 神经生物学 干细胞&分化 过敏 移植 product.subtitle.recentcitations 第一作者 Liu, W 标题 hUC-MSCs Attenuate Acute Graft-Versus-Host Disease through Chi3l1 Repression of Th17 Differentiation. 文献引用 Stem Cells International; 2022 pg1052166 PubMed Id 36277038 第一作者 Magusali, N 标题 A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. 文献引用 Brain : A Journal Of Neurology; 144(12) pg3727-3741 PubMed Id 34619763 第一作者 Wang, Y 标题 Cromolyn inhibits the secretion of inflammatory cytokines by human microglia (HMC3) 文献引用 Scientific Reports; 11(1) pg8054 PubMed Id 33850164