Recombinant Human IGF-BP2 0 评论Submit a Review 产品详情 产品编号： 350-06B 产品描述： IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich, secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant Human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. Source: (BTI-Tn-5B1-4) Hi-5 Insect cells Synonyms: Insulin-like Growth Factor-Binding Protein 2, IBP-2 AA Sequence: EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells. Calculated Molecular Weight: 31.5 kDa Accession Number: P18065 Gene ID: 3485 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 癌症 糖尿病/体重调节 product.subtitle.recentcitations 第一作者 Stephenson, S 标题 Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells. 文献引用 Journal of immunology (Baltimore, Md. : 1950); 202(4) pg1287-1300 PubMed Id 30642980 第一作者 Qin, E Y 标题 Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma. 文献引用 Cell; 170(5) pg845-859.e19 PubMed Id 28823557 第一作者 Nixon, C C 标题 Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected]. 文献引用 Scientific Reports; 5 pg8670 PubMed Id 25728014
