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无动物成分细胞因子

Animal-Free Recombinant Human IGF-BP3

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Product Details

Catalogue Number: AF-100-08
Description:
Animal-Free Recombinant Human IGF-BP3

IGF-BP3 is a 30 kDa, cysteine-rich secreted protein.  It is the major IGF binding protein present in the plasma of human and animals, and it is also found in α-granules of platelets.  In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity.  Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly.  The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors, such as Bombesin, Vasopressin, PDGF, and EGF.  Recombinant Human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Insulin-like Growth, Factor-Binding Protein3, IBP-3, Growth-hormone-dependent binding protein

AA Sequence: GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit IGF-II induced proliferation of MCF-7.  The expected ED50 is ≤ 0.2 μg/ml in the presence of 15 ng/ml of human IGF-II.

Animal-Free Recombinant Human IGF-BP3 Biological Activity Graph Animal-Free Recombinant Human IGF-BP3 Biological Activity Graph

Calculated Molecular Weight: 28.8 kDa

Accession Number: P17936

Gene ID: 3486

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)

Country Of Origin: USA

Not for human use.

Research Interest