Recombinant Human IGF-I 1 评论Submit a Review 产品详情 产品编号: 100-11 产品描述: The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-I is 7.6 kDa. Source: E.coli Synonyms: Insulin-like Growth Factor-I, Somatamedin C, IGF-IA AA Sequence: GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 7.6 kDa Accession Number: P05019 Gene ID: 3479 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Chicken, Cow, Dog, Frog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat, Salamander, Sheep, Zebra Fish References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 骨/骨骼系统/软骨 糖尿病/体重调节 免疫系统 炎症 神经生物学 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Chen, W 标题 Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors. 文献引用 Communications Biology; 6(1) pg393 PubMed Id 37041280 第一作者 Pinto-Benito, D 标题 IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner. 文献引用 Glia; 70(6) pg1153-1169 PubMed Id 35175663 第一作者 Li, T 标题 Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies. 文献引用 Cell Proliferation; 55(4) pge13212 PubMed Id 35274780 product.subtitle.productreviews 现有评论 IGF-1 for Endometrial Organoid Culture Successfully cultured Endometrial Organoids using IGF-1 and HGF from Peprotech.Quick Overnight Delivery is great. 来自: Hardik | 日期: 2020/8/31 × IGF-1 for Endometrial Organoid Culture Successfully cultured Endometrial Organoids using IGF-1 and HGF from Peprotech.Quick Overnight Delivery is great. 来自: Hardik | 日期: 2020/8/31 Close