Animal-Free Recombinant Human IGF-I 0 评论Submit a Review 产品详情 产品编号: AF-100-11 产品描述: The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-I is 7.6 kDa. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Insulin-like Growth Factor-I, Somatamedin C, IGF-IA AA Sequence: GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 7.6 kDa Accession Number: P05019 Gene ID: 3479 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Bacteria, Chicken, Cow, Frog, Horse, Human, Monkey, Mouse, Pig, Rat, Salamander, Sheep References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 骨/骨骼系统/软骨 糖尿病/体重调节 免疫系统 炎症 神经生物学 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Sissaoui, S 标题 Hyperglycaemia up-regulates placental growth factor (PlGF) expression and secretion in endothelial cells via suppression of PI3 kinase-Akt signalling and activation of FOXO1 文献引用 Scientific Reports; 11(1) pg16344 PubMed Id 34381074 第一作者 James, O G 标题 iPSC-derived myelinoids to study myelin biology of humans. 文献引用 Developmental Cell; 56(9) pg1346-1358.e6 PubMed Id 33945785 第一作者 García-León, J A 标题 Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells. 文献引用 Nature Protocols; 15(11) pg3716-3744 PubMed Id 33097924