IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant Human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.
Source:
Hi-5 Insect cells
Synonyms:
Interleukin-12 subunit beta, IL-12 subunit p40, IL-12B, Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40), NK cell Stimulating Factor Chain 2
AA Sequence:
p40 subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS
Purity:
≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Not available.
Calculated Molecular Weight:
80 kDa
Accession Number:
P29460
Gene ID:
3593
Endotoxin:
Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)
Note:
100μg is the largest vial size for this product.
Larger sizes supplied as multiple 50μg and/or 100μg vials.
Not for human use.
