Animal-Free Recombinant Human IL-13 0 评论Submit a Review 产品详情 产品编号: AF-200-13 产品描述: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. Recombinant Human IL-13 is a 12.6 kDa protein consisting of 115 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: NC30 (Human), P600 (Murine) AA Sequence: MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGRFN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥1 x 106 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 12.6 kDa Accession Number: P35225 Gene ID: 3596 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 艾滋病/HIV 癌症 免疫系统 炎症 干细胞&分化 过敏 product.subtitle.recentcitations 第一作者 Wang, S 标题 USP24 promotes drug resistance during cancer therapy 文献引用 Cell Death and Differentiation; 28(9) pg2690-2707 PubMed Id 33846536 第一作者 Buzza, M S 标题 Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis. 文献引用 The Journal of Biological Chemistry; 292(26) pg10801-10812 PubMed Id 28490634 第一作者 Alevy, Y G 标题 IL-13-induced airway mucus production is attenuated by MAPK13 inhibition. 文献引用 The Journal of Clinical Investigation; 122(12) pg4555-68 PubMed Id 23187130