Animal-Free Recombinant Human IL-1RA

产品详情

产品编号： AF-200-01RA

产品描述：

Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: IL-1Ra, ICIL-1RA, IRAP, IL-1RN

AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED₅₀ is 20-40 ng/ml in the presence of 50 pg/ml of IL-1alpha.

Calculated Molecular Weight: 17.2 kDa

Accession Number: P18510

Gene ID: 3554

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)

crossreactivity:

Frog, Human, Mouse, Rat