Recombinant Human IL-23 0 评论Submit a Review 产品详情 产品编号： 200-23 产品描述： IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ1. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17-mediated responses. Recombinant Human IL-23 is a 53.5 kDa, heterodimeric protein consisting of the two subunits, p19 (170 amino acids) and p40 (306 amino acids). Source: (BTI-Tn-5B1-4) Hi-5 Insect cells Synonyms: Interleukin-23 AA Sequence: p19 Subunit: RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of HEK-Blue™ IL-23 reporter cells. Calculated Molecular Weight: 53.5 kDa Accession Number: p19: Q9NPF7 p40: P29460 Gene ID: p19: 51561 p40: 3593 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 癌症 免疫系统 炎症 神经生物学 过敏 product.subtitle.recentcitations 第一作者 Wu, H 标题 The IL-21-TET2-AIM2-c-MAF pathway drives the T follicular helper cell response in lupus-like disease. 文献引用 Clinical And Translational Medicine; 12(3) pge781 PubMed Id 35343082 第一作者 Krzywinska, E 标题 The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut. 文献引用 The Journal of Experimental Medicine; 219(2) PubMed Id 35024767 第一作者 Jang, Y 标题 Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β. 文献引用 Journal of immunology (Baltimore, Md. : 1950); 207(10) pg2456-2464 PubMed Id 34615735
