Recombinant Human Leptin 0 评论Submit a Review 产品详情 产品编号: 300-27 产品描述: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Human Leptin is a 16.0 kDa protein containing 147 amino acid residues. Source: E.coli Synonyms: Obesity protein (OB) AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY STEVVALSRL QGSLQDMLWQ LDLSPGC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: PeproTech's Human Leptin is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed compared to saline-treated controls. Calculated Molecular Weight: 16 kDa Accession Number: P41159 Gene ID: 3952 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Chicken, Human, Monkey, Mouse, Pig, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 糖尿病/体重调节 免疫系统 炎症 神经生物学 创伤修复 product.subtitle.recentcitations 第一作者 Gaudino, S J 标题 Cutting Edge: Intestinal IL-17A Receptor Signaling Specifically Regulates High-Fat Diet-Mediated, Microbiota-Driven Metabolic Disorders. 文献引用 Journal of immunology (Baltimore, Md. : 1950); 207(8) pg1959-1963 PubMed Id 34544802 第一作者 Deng, J 标题 The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses. 文献引用 Nature Communications; 12(1) pg3073 PubMed Id 34031386 第一作者 Iqbal, J 标题 Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids. 文献引用 The Journal of Biological Chemistry; 295(13) pg4101-4113 PubMed Id 32047110