Recombinant Human MDC (CCL22) (67 a.a.) 0 评论Submit a Review 产品详情 产品编号: 300-36 产品描述: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells, and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. Source: E.coli Synonyms: Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1 AA Sequence: YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 8 kDa Accession Number: O00626 Gene ID: 6367 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Hamster, Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 艾滋病/HIV 化学趋化 免疫系统 创伤修复 product.subtitle.recentcitations 第一作者 Anderson, C A 标题 A degradatory fate for CCR4 suggests a primary role in Th2 inflammation. 文献引用 Journal of Leukocyte Biology; 107(3) pg455-466 PubMed Id 32052476 第一作者 Pickering, R J 标题 Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis. 文献引用 The Journal of Clinical Investigation; 129(1) pg406-421 PubMed Id 30530993 第一作者 Zhang, Y 标题 A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma. 文献引用 Scientific Reports; 7(1) pg15038 PubMed Id 29118379