Recombinant Human Pleiotrophin 0 评论Submit a Review 产品详情 产品编号： 450-15 产品描述： Pleiotrophin and Midkine are structurally related heparin-binding neurotrophic factors, whose expression is developmentally regulated. The expression pattern of these neurotrophic factors suggests function in neurogenesis, cell migration, secondary organogenetic induction, and mesoderm epithelial interaction. The expression of PTN increases during the process of brain embryogenesis, and reaches maximum levels at time of birth. The physiological roles of PTN and Midkine are largely unknown, but these neurotrophins have been implicated in the pathogenesis of neuroblastomas. Recombinant Human Pleiotrophin is a 15.4 kDa protein containing 136 amino acid residues and five intra-molecular disulfide bonds. Source: E.coli Synonyms: PTN, Heparin Affin Regulatory Protein (HARP), Heparin-binding growth factor-8(HBGF-8), Osteoblast-Specific Factor-1 (OSF-1) AA Sequence: GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 15.4 kDa Accession Number: P21246 Gene ID: 5764 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Chicken, Hamster, Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 神经生物学 干细胞&分化 product.subtitle.recentcitations 第一作者 Notaras, M 标题 Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids. 文献引用 Molecular Psychiatry; 27(3) pg1416-1434 PubMed Id 34789849 第一作者 Arnold, N 标题 A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. 文献引用 Nature Communications; 10(1) pg5183 PubMed Id 31729368 第一作者 Lampropoulou, E 标题 Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration. 文献引用 Scientific Reports; 8(1) pg5893 PubMed Id 29651006
