Recombinant Human Resistin 0 评论Submit a Review 产品详情 产品编号: 450-19 产品描述: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The four known members of this family, resistin, RELMα, RELMβ, and RELMγ, share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that resistin expression is severely suppressed in obesity, and that it may act as a feedback regulator of Adipogenesis. Recombinant Human Resistin is a 19.5 kDa, disulfide-linked, homodimeric protein composed of two identical 92 amino acid chains linked by a single disulfide bond. Source: E.coli Synonyms: FIZZ3, Adipose tissue-specific secretory factor, ADSF AA Sequence (monomer): SSKTLCSMEE AINERIQEVA GSLIFRAISS IGLECQSVTS RGDLATCPRG FAVTGCTCGS ACGSWDVRAE TTCHCQCAGM DWTGARCCRV QP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate lipolysis in cultured human adipocytes. (Ort, T. et al. Endocrinology; 46(5):2200-9) Calculated Molecular Weight: 19.5 kDa Accession Number: Q9HD89 Gene ID: 56729 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 糖尿病/体重调节 免疫系统 炎症 product.subtitle.recentcitations 第一作者 Zhang, L 标题 Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. 文献引用 Cell; 181(2) pg442-459.e29 PubMed Id 32302573 第一作者 Joshi, P 标题 The membrane-associated fraction of cyclase associate protein 1 translocates to the cytosol upon platelet stimulation. 文献引用 Scientific Reports; 8(1) pg10804 PubMed Id 30018317 第一作者 Jang, J C 标题 Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction. 文献引用 Proceedings of the National Academy of Sciences of the United States of America; 114(48) pgE10399-E10408 PubMed Id 29133417