Recombinant Human sIL-6 Receptor α (CHO derived) 0 评论Submit a Review 产品详情 产品编号: 200-06RC 产品描述: IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. While the IL-6Rα chain is the binding component specific to IL-6, the gp130 chain only transmits signals of IL-6 when bound to IL-6Rα. The gp130 can also transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Rα alone. IL-6Rα is expressed in a wide range of cells, including T cells, fibroblasts and macrophages. Soluble IL-6Rα, which consists of only the extracellular domain of the IL-6Rα chain, acts as an agonist of IL-6 activity at low concentrations. PeproTech's CHO cell-derived Recombinant Human sIL-6 Receptor α is a 37.9 kDa glycoprotein corresponding to 339 amino acid residues of the extracellular domain of IL-6Rα. As a result of glycosylation, Recombinant Human sIL-6 Receptor α migrates with an apparent molecular mass of approximately 57-70 kDa by SDS-PAGE gel, under reducing conditions. Source: CHO cells Synonyms: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126 AA Sequence: LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to intensify the IL-6 induced growth inhibition of mouse M1 cells. The expected ED50 is ≤ 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6. Calculated Molecular Weight: 37.9 kDa Accession Number: P08887 Gene ID: 3570 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 免疫系统 炎症 神经生物学 受体 干细胞&分化 product.subtitle.recentcitations 第一作者 Zhang, B 标题 CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases. 文献引用 The Journal of Experimental Medicine; 219(2) PubMed Id 35015026 第一作者 Luan, X 标题 Cyclophilin A is a key positive and negative feedback regulator within interleukin-6 trans-signaling pathway. 文献引用 FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 35(11) pge21958 PubMed Id 34606626 第一作者 Bent, E H 标题 Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy. 文献引用 Nature Communications; 12(1) pg6218 PubMed Id 34711820