Recombinant Human sTNF Receptor Type I 0 评论Submit a Review 产品详情 产品编号: 310-07 产品描述: TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein. Source: E.coli Synonyms: Soluble Tumor Necrosis Factor Type I, TNFRSF1A, TNFAR, TNFR60, p55, CD120a AA Sequence: MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-α, is 0.05 µg/ml. Calculated Molecular Weight: 18.3 kDa Accession Number: P19438 Note: 1mg will be provided as 2x500μg. Gene ID: 7132 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Alpaca, Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 细胞凋亡 免疫系统 炎症 神经生物学 受体 干细胞&分化 TNF超家族 product.subtitle.recentcitations 第一作者 Zheng, Z 标题 Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis. 文献引用 Scientific Reports; 6 pg25672 PubMed Id 27158082 第一作者 Steeland, S 标题 Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1. 文献引用 The Journal of Biological Chemistry; 290(7) pg4022-37 PubMed Id 25538244 第一作者 Zhan, J 标题 Fusion of HSA influences TNF-α neutralizing activity of shTNFRs. 文献引用 Biotechnology Letters; 34(3) pg417-23 PubMed Id 22083716