Recombinant Human TGF-β3 0 评论Submit a Review 产品详情 产品编号: 100-36E 产品描述: The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown, but its expression pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond. Source: E.coli Synonyms: Transforming Growth Factor-β3 AA Sequence (monomer): ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 25 kDa Accession Number: P10600 Gene ID: 7043 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Cow, Dog, Horse, Human, Human + Rat, Human + Virus, Monkey, Mouse, Pig, Rat, Sheep References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 癌症 免疫系统 炎症 神经生物学 干细胞&分化 TGF-β超家族 创伤修复 过敏 product.subtitle.recentcitations 第一作者 Sabate-Soler, S 标题 Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality. 文献引用 Glia; 70(7) pg1267-1288 PubMed Id 35262217 第一作者 Hanuscheck, N 标题 Interleukin-4 receptor signaling modulates neuronal network activity. 文献引用 The Journal of Experimental Medicine; 219(6) PubMed Id 35587822 第一作者 Rasińska, J 标题 Transposon-mediated glial cell line-derived neurotrophic factor overexpression in human adipose tissue-derived mesenchymal stromal cells: A potential approach for neuroregenerative medicine? 文献引用 Journal Of Tissue Engineering And Regenerative Medicine; 16(6) pg515-529 PubMed Id 35278347