Recombinant Human VEGF-D 0 评论Submit a Review 产品详情 产品编号: 100-20D 产品描述: VEGF-D, a member of the VEGF/PDGF family of structurally-related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogenesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surface-associated, non-covalent, disulfide-linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant Human VEGF-D is a 26.2 kDa, non-disulfide linked, homodimeric protein consisting of two 117 amino acid polypeptide chains. Due to glycosylation, the protein migrates as a 20.0-22.0 kDa band by SDS-PAGE analysis under non-reducing conditions. Source: HEK293 cells Synonyms: Vascular Endothelial Growth Factor-D, FIGF AA Sequence (monomer): FAATFYDIET LKVIDEEWQR TQCSPRETCV EVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTG CKCLPTAPRH PYSIIRR Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to bind recombinant human VEGFR3/Flt-4 Fc in a functional ELISA. Calculated Molecular Weight: 26.2 kDa Accession Number: O43915 Gene ID: 2277 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 癌症 免疫系统 炎症 干细胞&分化 product.subtitle.recentcitations 第一作者 Guo, R 标题 Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors. 文献引用 Cell Research; 30(1) pg21-33 PubMed Id 31729468