Recombinant Human WISP-1 0 评论Submit a Review 产品详情 产品编号： 120-18 产品描述： WISP-1 is a member of the CCN family of secreted, cysteine-rich regulatory proteins. It is expressed in the heart, kidney, lung, pancreas, placenta, ovary, small intestine and spleen. WISP-1 is a β-catenin-regulated protein that can contribute to tumorigenesis, and has also been shown to play a role in bone development and fracture repair. Recombinant Human WISP-1 is a 38.1 kDa protein containing 345 amino acid residues. It is composed of four distinct structural domains (modules): the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the thrombospondin type-1 repeat (TSP type-1) domain, and a C-terminal cysteine knot-like (CTCK) domain. Source: E.coli Synonyms: WNT-1 inducible signaling pathway protein-1, CCN4, Wnt-1-induced secreted protein AA Sequence: TALSPAPTTM DFTPAPLEDT SSRPQFCKWP CECPPSPPRC PLGVSLITDG CECCKMCAQQ LGDNCTEAAI CDPHRGLYCD YSGDRPRYAI GVCAQVVGVG CVLDGVRYNN GQSFQPNCKY NCTCIDGAVG CTPLCLRVRP PRLWCPHPRR VSIPGHCCEQ WVCEDDAKRP RKTAPRDTGA FDAVGEVEAW HRNCIAYTSP WSPCSTSCGL GVSTRISNVN AQCWPEQESR LCNLRPCDVD IHTLIKAGKK CLAVYQPEAS MNFTLAGCIS TRSYQPKYCG VCMDNRCCIP YKSKTIDVSF QCPDGLGFSR QVLWINACFC NLSCRNPNDI FADLESYPDF SEIAN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependant proliferation of the MCF-7 cell line. The expected ED50 for this effect is 1.0-3.0 µg/ml. Calculated Molecular Weight: 38.1 kDa Accession Number: O95388 Gene ID: 8840 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 骨/骨骼系统/软骨 癌症 免疫系统 神经生物学 干细胞&分化 product.subtitle.recentcitations 第一作者 Maeda, A 标题 WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. 文献引用 The Journal of Biological Chemistry; 290(22) pg14004-18 PubMed Id 25864198 第一作者 Venkatachalam, K 标题 WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death. 文献引用 The Journal of Biological Chemistry; 284(21) pg14414-27 PubMed Id 19339243 第一作者 Colston, J T 标题 Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor. 文献引用 American journal of physiology. Heart and circulatory physiology; 293(3) pgH1839-46 PubMed Id 17616748
