无动物成分细胞因子

Animal-Free Recombinant Human/Murine/Rat BDNF

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Product Details

Catalogue Number: AF-450-02
Description:

BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Brain Derived Neurotrophic Factor, Abrineurin

AA Sequence (monomer): MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 27 kDa

Accession Number: P23560

Gene ID: 627

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Foo, L C
Title
Development of a method for the purification and culture of rodent astrocytes.
Citation
Neuron; 71(5) pg799-811
PubMed Id
First Author
Swanger, S A
Title
Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model.
Citation
Molecular Brain; 4 pg38
PubMed Id
First Author
Dong, Q
Title
LIM kinase 1 (LIMK1) interacts with tropomyosin-related kinase B (TrkB) and Mediates brain-derived neurotrophic factor (BDNF)-induced axonal elongation.
Citation
The Journal of Biological Chemistry; 287(50) pg41720-31
PubMed Id