Animal-Free Recombinant Human/Murine/Rat BDNF 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-450-02 Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Brain Derived Neurotrophic Factor, Abrineurin AA Sequence (monomer): MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 27 kDa Accession Number: P23560 Gene ID: 627 crossreactivity: Chicken, Frog, Guinea Pig, Hamster, Human, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Foo, L C Title Development of a method for the purification and culture of rodent astrocytes. Citation Neuron; 71(5) pg799-811 PubMed Id 21903074 First Author Swanger, S A Title Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model. Citation Molecular Brain; 4 pg38 PubMed Id 21982080 First Author Dong, Q Title LIM kinase 1 (LIMK1) interacts with tropomyosin-related kinase B (TrkB) and Mediates brain-derived neurotrophic factor (BDNF)-induced axonal elongation. Citation The Journal of Biological Chemistry; 287(50) pg41720-31 PubMed Id 23086941
