Recombinant Human/Murine/Rat Myostatin 0 评论Submit a Review 产品详情 产品编号: 120-00 产品描述: Myostatin is a TGF-β family member that acts as an inhibitor of skeletal muscle growth. This muscle-specific cytokine interacts with Activin type I and type II receptors, and suppresses myoblast proliferation by arresting cell-cycle in the G1 phase. Suppression of myostatin activity facilitates muscle formation, and may be useful in reducing and/or preventing adiposity and type-2 diabetes. Myostatin activity can be blocked by the activin-binding protein follistatin, and by the propeptide of myostatin. Recombinant Human/Murine/Rat Myostatin is a 25.0 kDa protein consisting of two identical 109 amino acid polypeptides linked by a single disulfide bond. The amino acid sequence of mature myostatin is extremely conserved across species, and is the same in murine, rat, chicken, turkey, porcine, and human. Myostatin is expressed as the C-terminal part of a precursor polypeptide, which also contains a short N-terminal signal sequence for secretion, and a propeptide of 243 amino acids. After dimerization of this precursor, the covalent bonds between the propeptide and the mature ligand are cleaved by furin-type proteases. However, the resulting two proteins remain associated through non-covalent interactions, and are secreted as a latent complex. Source: E.coli Synonyms: GDF-8 AA Sequence (monomer): DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the proliferation of MPC-11 cells. The expected ED50 for this effect is 17.0-25.0 ng/ml. Calculated Molecular Weight: 25 kDa Accession Number: O14793 Gene ID: 2660 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 骨/骨骼系统/软骨 糖尿病/体重调节 免疫系统 干细胞&分化 product.subtitle.recentcitations 第一作者 Verzola, D 标题 Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy. 文献引用 Scientific Reports; 10(1) pg6343 PubMed Id 32286342 第一作者 Walker, R G 标题 Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice 文献引用 Scientific Reports; 10(1) pg4561 PubMed Id 32165710 第一作者 Ozek, C 标题 Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice. 文献引用 Scientific Reports; 8(1) pg17293 PubMed Id 30470794