Recombinant Murine IL-21 1 评论Submit a Review 产品详情 产品编号: 210-21 产品描述: IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T cell-stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naïve B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues. Source: E.coli Synonyms: Interleukin-21, Za11 AA Sequence: MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Assay #1: Measured by its ability to induce STAT3 signaling in U937 Stat3-Luc reporter cells. Assay #2: Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expected ED50 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 15 kDa Accession Number: Q9ES17 Gene ID: 60505 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell 细胞凋亡 癌症 免疫系统 干细胞&分化 product.subtitle.recentcitations 第一作者 Chang, J Y 标题 Co-Anchoring of Engineered Immunogen and Immunostimulatory Cytokines to Alum Promotes Enhanced-Humoral Immunity. 文献引用 Advanced Therapeutics; 5(7) pg2100235 PubMed Id 36311814 第一作者 Di Pietro, A 标题 Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection. 文献引用 Nature Immunology; 23(1) pg86-98 PubMed Id 34845392 第一作者 Jang, Y 标题 Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β. 文献引用 Journal of immunology (Baltimore, Md. : 1950); 207(10) pg2456-2464 PubMed Id 34615735 product.subtitle.productreviews 现有评论 Excellent product Works very nice for mouse B cell culture 来自: Alexander | 日期: 2020/7/15 × Excellent product Works very nice for mouse B cell culture 来自: Alexander | 日期: 2020/7/15 Close