Animal-Free Recombinant Murine IL-3 0 评论Submit a Review 产品详情 产品编号： AF-213-13 产品描述： IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor AA Sequence: MDTHRLTRTL NCSSIVKEII GKLPEPELKT DDEGPSLRNK SFRRVNLSKF VESQGEVDPE DRYVIKSNLQ KLNCCLPTSA NDSALPGVFI RDLDDFRKKL RFYMVHLNDL ETVLTSRPPQ PASGSVSPNR GTVEC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of mouse NFS-60 cells is ≤0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 15.1 kDa Accession Number: P01586 Gene ID: 16187 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Gerbil, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 艾滋病/HIV 癌症 细胞培养 糖尿病/体重调节 免疫系统 干细胞&分化 product.subtitle.recentcitations 第一作者 De Munck, S 标题 Structural basis of cytokine-mediated activation of ALK family receptors 文献引用 Nature; 600(7887) pg143-147 PubMed Id 34646012 第一作者 Quambusch, L 标题 Cellular model system to dissect the isoform-selectivity of Akt inhibitors 文献引用 Nature Communications; 12(1) pg5297 PubMed Id 34489430 第一作者 Moccia, M 标题 Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases 文献引用 Scientific Reports; 11(1) pg16103 PubMed Id 34373541
