Animal-Free Recombinant Murine IL-6 0 评论Submit a Review 产品详情 产品编号: AF-216-16 产品描述: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6Rα and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: 26 kDa protein, IFN-β2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 AA Sequence: MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse B9 cells. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 21.7 kDa Accession Number: P08505 Gene ID: 16193 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human + Mouse, Monkey, Mouse, Mouse + Bacteria, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 血管生成/心血管 癌症 细胞培养 糖尿病/体重调节 免疫系统 炎症 神经生物学 干细胞&分化 创伤修复 过敏 移植 product.subtitle.recentcitations 第一作者 Duan, H 标题 CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity. 文献引用 Advanced science (Weinheim, Baden-Wurttemberg, Germany); 9(13) pge2103719 PubMed Id 35258174 第一作者 Fiancette, R 标题 Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity 文献引用 Nature Immunology; 22(10) pg1245-1255 PubMed Id 34556884 第一作者 Sapra, L 标题 Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice. 文献引用 Scientific Reports; 11(1) pg1807 PubMed Id 33469043