Recombinant Murine Leptin 0 评论Submit a Review 产品详情 产品编号: 450-31 产品描述: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Murine Leptin is a 16.2 kDa protein containing 147 amino acid residues. Source: E.coli Synonyms: Obesity protein (OB) AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: PeproTech's Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls. Calculated Molecular Weight: 16.2 kDa Accession Number: P41160 Gene ID: 16846 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Hamster, Human, Monkey, Mouse, Pig, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 细胞凋亡 糖尿病/体重调节 免疫系统 炎症 神经生物学 创伤修复 product.subtitle.recentcitations 第一作者 Porniece Kumar, M 标题 Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. 文献引用 Nature Metabolism; 3(12) pg1662-1679 PubMed Id 34931084 第一作者 Heiss, C N 标题 The gut microbiota regulates hypothalamic inflammation and leptin sensitivity in Western diet-fed mice via a GLP-1R-dependent mechanism. 文献引用 Cell Reports; 35(8) pg109163 PubMed Id 34038733 第一作者 Takenaga, K 标题 Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice. 文献引用 Scientific Reports; 11(1) pg2923 PubMed Id 33536560