Recombinant Murine LIGHT 0 评论Submit a Review 产品详情 产品编号： 315-12 产品描述： LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD8+ tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to activate NF-κB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant Murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues, comprising the TNF-homologous region of the LIGHT extracellular domain. Source: E.coli Synonyms: TNFSF14, HVEM-L AA Sequence: MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANASLIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ LSGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSSRVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FMV Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its cytotoxic effecton HT-29 cells (human colon adenocarcinoma cells) in the presence of human IFN-γ. Calculated Molecular Weight: 20.1 kDa Accession Number: Q9QYH9 Gene ID: 50930 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 细胞凋亡 癌症 免疫系统 炎症 TNF超家族 product.subtitle.recentcitations 第一作者 Waldemer-Streyer, R J 标题 Myocyte-derived Tnfsf14 is a survival factor necessary for myoblast differentiation and skeletal muscle regeneration. 文献引用 Cell death & disease; 6 pge2026 PubMed Id 26720335 第一作者 Pontejo, S M 标题 Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors. 文献引用 The Journal of Biological Chemistry; 290(26) pg15973-84 PubMed Id 25940088 第一作者 Fan, K 标题 Preparation and characterization of a monoclonal antibody against the protein LIGHT. 文献引用 Hybridoma (2005); 24(6) pg309-13 PubMed Id 16332198
