Recombinant Murine PDGF-AA 0 评论Submit a Review 产品详情 产品编号: 315-17 产品描述: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Murine PDGF-AA is a 28.7 kDa disulfide-linked homodimer of two A chains (250 total amino acids). Source: E.coli Synonyms: Platelet-Derived Growth Factor-AA, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF) AA Sequence (monomer): SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATSNLNP DHREEETGRR RESGKNRKRK RLKPT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 8-10 ng/ml. Calculated Molecular Weight: 28.7 kDa Accession Number: P20033 Gene ID: 18590 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 骨/骨骼系统/软骨 癌症 免疫系统 神经生物学 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Wang, Y 标题 PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination. 文献引用 Cell Reports; 37(1) pg109695 PubMed Id 34610310 第一作者 Boshans, L L 标题 Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2 文献引用 Scientific Reports; 11(1) pg3552 PubMed Id 33574458 第一作者 Floriddia, E M 标题 Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury. 文献引用 Nature Communications; 11(1) pg5860 PubMed Id 33203872