Recombinant Murine PDGF-BB 1 评论Submit a Review 产品详情 产品编号: 315-18 产品描述: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Murine PDGF-BB is a 24.4 kDa disulfide-linked homodimer of two β chains (218 total amino acids). Source: E.coli Synonyms: Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF) AA Sequence (monomer): SLGSLAAAEP AVIAECKTRT EVFQISRNLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RASQVQMRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TIVTPRPVT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-2.0 ng/ml. Calculated Molecular Weight: 24.4 kDa Accession Number: P31240 Gene ID: 18591 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Monkey, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 骨/骨骼系统/软骨 癌症 免疫系统 神经生物学 干细胞&分化 创伤修复 product.subtitle.recentcitations 第一作者 Chen, X 标题 Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2'3'-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation. 文献引用 Journal of immunology (Baltimore, Md. : 1950); 206(9) pg2061-2074 PubMed Id 33827893 第一作者 Herdenberg, C 标题 LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes. 文献引用 Communications Biology; 4(1) pg90 PubMed Id 33469151 第一作者 Alqawlaq, S 标题 An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14. 文献引用 The Journal of Biological Chemistry; PubMed Id 33234594 product.subtitle.productreviews 现有评论 Good! Worked as described! 来自: Lillian | 日期: 2020/7/21 × Good! Worked as described! 来自: Lillian | 日期: 2020/7/21 Close