Recombinant Murine Resistin 0 评论Submit a Review 产品详情 产品编号: 450-28 产品描述: Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The four known members of this family, resistin, RELMα, RELMβ, and RELMγ, share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that resistin expression is severely suppressed in obesity, and that it may act as a feedback regulator of Adipogenesis. Recombinant Murine Resistin is a 20.2 kDa, disulfide-linked, homodimeric protein composed of two identical 94 amino acid chains linked by a single disulfide bond. Source: E.coli Synonyms: FIZZ3, Adipose tissue-specific secretory factor, ADSF AA Sequence (monomer): SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN IGLNCWTVSS RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI DWTAARCCKL QVAS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 20.2 kDa Accession Number: Q99P87 Gene ID: 57264 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 血管生成/心血管 糖尿病/体重调节 免疫系统 炎症 product.subtitle.recentcitations 第一作者 Junkin, K A 标题 Resistin acutely impairs insulin-stimulated glucose transport in rodent muscle in the presence, but not absence, of palmitate. 文献引用 American journal of physiology. Regulatory, integrative and comparative physiology; 296(4) pgR944-51 PubMed Id 19193939 第一作者 Bokarewa, M 标题 Resistin, an adipokine with potent proinflammatory properties. 文献引用 Journal of immunology (Baltimore, Md. : 1950); 174(9) pg5789-95 PubMed Id 15843582 第一作者 Ort, T 标题 Recombinant human FIZZ3/resistin stimulates lipolysis in cultured human adipocytes, mouse adipose explants, and normal mice. 文献引用 Endocrinology; 146(5) pg2200-9 PubMed Id 15705777