Recombinant Rat Oncostatin M 0 评论Submit a Review 产品详情 产品编号： 400-36 产品描述： Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Recombinant Rat Oncostatin M is a 24.4 kDa protein, containing 215 amino acid residues. Source: E.coli Synonyms: OSM AA Sequence: MKRGCSSSSP KLLSQLKSQA NITGNTASLL EPYILHQNLN TLTLRAACTE HPVAFPSEDM LRQLSKPDFL STVHATLGRV WHQLGAFRQQ FPKIQDFPEL ERARQNIQGI RNNVYCMARL LHPPLEIPEP TQADSGTSRP TTTAPGIFQI KIDSCRFLWG YHRFMGSVGR VFEEWGDGSR RSRRHSPLWA WLKGDHRIRP SRSSQSAMLR SLVPR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Assay #1:Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 is 3.0-5.0 μg/ml. Assay #2: Determined by its ability to inhibit Alkaline phosphatase activity of differentiated MC3T3 E1 cells. Calculated Molecular Weight: 24.4 kDa Accession Number: Q65Z15 Gene ID: 289747 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 艾滋病/HIV 血管生成/心血管 骨/骨骼系统/软骨 免疫系统 炎症 神经生物学 干细胞&分化 product.subtitle.recentcitations 第一作者 Zhang, P 标题 Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice. 文献引用 Stem Cell Reports; 6(6) pg914-925 PubMed Id 27237378 第一作者 Drechsler, J 标题 Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor. 文献引用 PLoS ONE; 7(8) pge43155 PubMed Id 22937020
