FGF Superfamily

The Fibroblast Growth Factor (FGF) Superfamily is comprised of multifunctional proteins that serve to regulate a number of complex biological processes related to the development, restoration and/or redistribution of prenatal and postnatal tissue as well as angiogenesis, wound healing, nerve regeneration, chronic inflammation, and cancer growth.  Members of the FGF Superfamily function through paracrine, autocrine and intracrine pathways to promote spatial and temporal integrations of several cell responses, such as proliferation, growth, differentiation, and migration, While proteins of the FGF family exhibit only a modest degree of primary sequence homology, they preserve the ability to signal through at least one of four tyrosine kinase receptors, which include FGFR1 through FGFR4, and interact with heparin sulphate proteoglycans (HSPGs). Given the significance of fibroblast growth factor involvement within such an array of biological processes, and the abundance of conditions associated with deviations from normal FGF production and activity, understanding normal and aberrant FGF function has become critical to current research concerning the prevention and treatment of FGF-associated diseases.

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