Animal-Free Recombinant Human IL-3 0 ReviewsSubmit a Review Product Details Catalog Number: AF-200-03 Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoiesis, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is a species-specific, variably glycosylated cytokine. Recombinant Human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Interleukin-3, MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor AA Sequence: APMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. Calculated Molecular Weight: 15 kDa Accession Number: P08700 Gene ID: 3562 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Human + Mouse, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Stem Cells & Differentiation Recent Citations First Author Chen, W Title Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors. Citation Communications Biology; 6(1) pg393 PubMed ID 37041280 First Author Eernstman, J Title Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals Citation Scientific Reports; 11(1) pg18557 PubMed ID 34535703 First Author Thornton, N Title Disruption of the tumour-associated EMP3 enhances erythrid proliferation and causes the MAM-negative phenotype Citation Nature Communications; 11(1) pg3569 PubMed ID 32678083