Recombinant Human sRANK Ligand (CHO derived) 0 评论Submit a Review 产品详情 产品编号: 310-01C 产品描述: RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK+ T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells,including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Human RANKL is reactive on murine cells. PeproTech's CHO cell-derived Recombinant Human sRANK Ligand is a 22.1 kDa polypeptide comprised of the TNF-homologous region of RANKL and a N-terminal His-tag. Source: CHO cells Synonyms: soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-Related Activation-induced Cytokine), OPGL, ODF (Osteoclast Differentiation Factor), CD254 AA Sequence: HHHHHHHHPS PGGSGGSQHI RAEKAMVDGS WLDLAKRSKL EAQPFAHLTI NATDIPSGSH KVSLSSWYHD RGWGKISNMT FSNGKLIVNQ DGFYYLYANI CFRHHETSGD LATEYLQLMV YVTKTSIKIP SSHTLMKGGS TKYWSGNSEF HFYSINVGGF FKLRSGEEIS IEVSNPSLLD PDQDATYFGA FKVRDID Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its dose-dependent ability to induce reporter gene in HT-29 NF-κB Luc reporter cells. Calculated Molecular Weight: 22.1 kDa Accession Number: O14788 Gene ID: 8600 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA 搜索 Product Line Country Of Origin: USA Not for human use. Research Interest 细胞凋亡 骨/骨骼系统/软骨 癌症 糖尿病/体重调节 免疫系统 TNF超家族 product.subtitle.recentcitations 第一作者 Kaur, K 标题 Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells. 文献引用 Scientific Reports; 10(1) pg20363 PubMed Id 33230147 第一作者 Yang, B 标题 Amyloid β peptide promotes bone formation by regulating Wnt/β-catenin signaling and the OPG/RANKL/RANK system. 文献引用 ACR Open Rheumatology; 34(3) pg3583-3593 PubMed Id 31944393 第一作者 Weivoda, M 标题 Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. 文献引用 Nature Communications; 11(1) pg87 PubMed Id 31911667