Recombinant Human BD-2 0 리뷰submitareview 제품 상세 카다로그 번호 300-49 제품 설명 Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant Human BD-2 is a 4.3 kDa protein containing 41 amino acid residues. Source: E.coli Synonyms: DEFB2, DEFB4A, Beta-Defensin 2, Skin-antimicrobial peptide 1, SAP1 AA Sequence: GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract immature human dendritic cells using a concentration of 10.0-100.0 ng/ml. Calculated Molecular Weight: 4.3 kDa Accession Number: O15263 Gene ID: 1673 crossreactivity: Bacteria, Human, Rat, Virus Research Interest Chemotaxis Immune System Stem Cells & Differentiation References PubMed SDS Product Line Country Of Origin: USA Not for human use.