Animal-Free Recombinant Human/Murine/Rat Activin A (E.coli derived) 0 리뷰submitareview 제품 상세 카다로그 번호 AF-120-14E 제품 설명 Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein, Erythroid Differentiation Factor (EDF) AA Sequence (monomer): GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 26 kDa Accession Number: P08476 Gene ID: 3624 Note: 1mg will be provided as 2x500μg. crossreactivity: Chicken, Dog, Frog, Human, Human + Mouse, Mouse, Rat Research Interest Organoids Angiogenesis/Cardiovascular Apoptosis Cancer Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily References PubMed SDS Product Line Country Of Origin: USA Not for human use.