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Neurotrophins

Recombinant Murine Artemin

제품 상세

카다로그 번호 450‐58
제품 설명

Artemin is a disulfide‐linked homodimeric neurotrophic factor structurally related to GDNF, neurturin and persephin. These proteins belong to the cysteine knot superfamily of growth factors that assume stable dimeric protein structures. Artemin, GDNF, persephin and neurturin all signal through a multicomponent receptor system, composed of RET (receptor tyrosine kinase) and one of the four GFRα (α1‐α4) receptors. Artemin prefers the receptor GFRα3‐RET, but will use other receptors as an alternative. Artemin supports the survival of all peripheral ganglia, such as sympathetic, neural crest and placodally‐derived sensory neurons, and dopaminergic midbrain neurons. The functional human artemin ligand is a disulfide‐linked homodimer of two 12.0 kDa polypeptide monomers. Each monomer contains seven conserved cysteine residues, one of which is used for interchain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine‐knot configuration. Recombinant Murine Artemin is a disulfide‐linked homodimer formed by two identical 113 amino acid subunits with a calculated molecular weight of 24.2 kDa. 

Source: E.coli

Synonyms: ART, ARTN, Enovin, Neublastin

AA Sequence (monomer): AGTRSSRART TDARGCRLRS QLVPVSALGL GHSSDELIRF RFCSGSCRRA RSQHDLSLAS LLGAGALRSP PGSRPISQPC CRPTRYEAVS FMDVNSTWRT VDHLSATACG CLG

Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of SH-SY5Y cells. The expected ED50 for this effect is 0.1-0.5 µg/ml.

Calculated Molecular Weight: 12.1 kDa

Accession Number: Q9Z0L2

Gene ID: 11876

Research Interest

Country Of Origin: USA

Not for human use.