Neurotrophin Chart Poster
|
Functional Name |
Synonyms |
Main Neurotrophic Functions (Partial List) |
Disease/Disorder (Partial List) |
Receptors |
| β-NGF (beta-Nerve Growth Factor) |
NGF-β |
Supports survival and maintenance of neurons in the sensory and sympathetic nervous systems | Alzheimer’s, Parkinson’s, diabetic peripheral neuropathy, cardiovascular diseases | LNGFR, gp140/trk, p75NTR |
| BDNF (Brain Derived Neurotrophic Factor) |
Abrineurin | Supports survival and maintenance of neurons in the central nervous system and peripheral nervous systems | Parkinson’s, diabetic peripheral neuropathy, ALS, Huntington’s | LNGFR, gp145/trkB, p75NTR |
| NNT-1/BCSF-3 (Novel Neurotrophin-1/ B-Cell Stimulating Factor-3) |
Cardiotrophin-like cytokine (CLCF1) | Supports survival of motor and sympathetic neurons in chick embryos | Multifocal neuronal hypoplasia, neurodegenerative eye diseases (glaucoma), CISS ( Cold-Induced Sweating Syndrome) | LIFR-β, gp130 |
| NT-3 (Neurotrophin-3) |
NGF-2, HGNF | Promotes growth and survival of new and existing neurons | Diabetic peripheral neuropathy, periodontal diseases | Trk, TrkB, TrkC, p75NTR |
| NT-4 (Neurotrophin-4) |
NT-4/NT-5 | Promotes survival of peripheral receptors sensory sympathetic neurons | Huntington’s, glaucoma | TrkB, p75NTR |
| GDNF (Glial-Derived Neurotrophic Factor) |
ATF-1 | Promotes dopamine uptake, survival and morphological differentiation of midbrain neurons | Parkinson’s, ALS, Huntington’s | RET/GFR1α-4α |
| MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor) |
ARMET, Arginine-Rich Protein (ARP) | Promotes survival, growth and function of dopamine specific neurons | Parkinson’s, cancer | Unknown at time of printing |
| CDNF (Cerebral Dopamine Neurotrophic Factor) |
ARMETL1 | Promotes survival, growth and function of dopamine specific neurons | Parkinson’s | Unknown at time of printing |
| CNTF (Ciliary Neurotrophic Factor) |
None | Promotes survival of ciliary neurons, primary sensory neurons, motor neu-rons, basal forebrain neurons, and type 2 astrocytes | ALS, Huntington’s | CNTFR-α |
| IL-6 (Interleukin-6) |
26 kDa protein, IFN-b2, B-cell Differentiation Factor (BCDF), BSF-2, HPGF, HSF, MGI-2 |
Involved in inflammation associated with Alzheimer’s disease | Diabetes, atherosclerosis, Alzheimer’s, depression, rheumatoid arthritis, systemic lupus, cancer, MS | IL-6Rα, gp130 |
| Oncostatin M | OSM | Involved in the regulation of neurogenesis | Rheumatoid arthritis, atherosclerosis, cancer, TEL/JAK2 disease | LIFR-high affinity, gp130-low affinity |
| Cardiotrophin-1 | CT-1 | Enhances survival of different neuronal populations | Motor Neuron Diseases (MND), cardiovascular diseases | gp130, LIFR |
| IL-11 (Interleukin-11) |
AGIF (Adipogenesis Inhibitory Factor) | Survival of oligodendrocytes, involved in inflammation associated with MS | Atherosclerosis, MS | IL-11Rα, gp130 |
| LIF (Leukemia Inhibitory Factor) |
Differentiation-stimulating factor, D-factor, Melanoma-Derived LPL inhibitor (MLPLI) |
Promotes stimulation of differentiation of cholinergic nerves | Systemic lupus, cancer, epidermal hyperplasia in ALS | LIFR |
| Pleiotrophin | PTN, Heparin Affin Regulatory Protein (HARP), Heparin-Binding Growth Factor-8 (HBGF-8), Osteoblast-Specific Factor 1 (OSF-1) |
Promotes neurite outgrowth | Angiogenesis, Parkinson’s, cancer | ALK |
| Midkine | MK, NEGF-2 | Promotes neurite outgrowth | Alzheimer’s, cancer | ALK |
| Neurturin | NTN, NRTN | Promotes survival of sympathetic and sensory neurons | Parkinson’s | Prefers RET/GFR2a |
| Artemin | ART, ARTN, Enovin, Neublastin | Promotes survival of sympathetic, neural crest, placodally-derived sensory neurons, and dopaminergic midbrain neurons | Chronic pain | Prefers RET/GFR3a |
| Persephin | PSP, PSPN | Promotes survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve oxotomy | Alzheimer’s | Prefers RET/GFR4a |