Representing a vast and complex network of cells, tissues, and organs, the immune system is comprised of several cell types, each having distinct and specialized functions such as engulfing bacteria, producing antibodies, and killing parasites, tumor cells and virally-infected cells, that collectively serve to protect the body from bacterial, fungal, and viral infections, as well as from the growth and dispersal of tumor cells. Representing a duality of responsibilities, the immune system initiates the body’s quick and efficient response to alien agents, while also distinguishing these threats from the body’s healthy cells in order to avoid attacks against the host; a process known as autoimmunity. Lymphocytes and other cells from the immune system, such as macrophages and dendritic cells, produce a large array of cell signaling proteins that are collectively referred to as cytokines, which are responsible for the intercellular communications necessary for the accurate and efficient performance of both innate and adaptive immune responses. Our understanding of the immune system has advanced significantly in recent years, and it has become evident that cytokines play a central role in the activation and regulation of the immune response.
View References for PeproTech’s products in Immune System Research:
DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8+ T Cell Compartment by Negatively Regulating Tonic TCR Triggering.
Author: Mahajan, V
The control of cytoskeletal dynamics by dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration.
Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation.
Author: Coden, M
In inflamed human tissues, we often find intact eosinophilic granules, but not eosinophils themselves. Eosinophils, tissue-dwelling granulocytes with several homeostatic roles, have a surprising association with fibrinogen and tissue remodeling.
Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.
Author: Losurdo, M
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression.