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Research Areas

Immune System

Representing a vast and complex network of cells, tissues, and organs, the immune system is comprised of several cell types, each having distinct and specialized functions such as engulfing bacteria, producing antibodies, and killing parasites, tumor cells and virally-infected cells, that collectively serve to protect the body from bacterial, fungal, and viral infections, as well as from the growth and dispersal of tumor cells.  Representing a duality of responsibilities, the immune system initiates the body’s quick and efficient response to alien agents, while also distinguishing these threats from the body’s healthy cells in order to avoid attacks against the host; a process known as autoimmunity. Lymphocytes and other cells from the immune system, such as macrophages and dendritic cells, produce a large array of cell signaling proteins that are collectively referred to as cytokines, which are responsible for the intercellular communications necessary for the accurate and efficient performance of both innate and adaptive immune responses.  Our understanding of the immune system has advanced significantly in recent years, and it has become evident that cytokines play a central role in the activation and regulation of the immune response.

View References for PeproTech’s products in Immune System Research:

DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8+ T Cell Compartment by Negatively Regulating Tonic TCR Triggering.

Author: Mahajan, V
The control of cytoskeletal dynamics by dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration.

MUC1 as a target for CAR-T therapy in head and neck squamous cell carinoma.

Author: Mei, Z
The modification of chimeric antigen receptor (CAR) endowing T cells with tumor-specific cytotoxicity induces antitumor immunity.

Pembrolizumab Interferes with the Differentiation of Human FOXP3+-Induced T Regulatory Cells, but Not with FOXP3 Stability, through Activation of mTOR.

Author: Sasidharan Nair, V
Programmed cell death 1 (PD-1) is critical for T regulatory cells (Tregs) to maintain peripheral tolerance to self-antigens.

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.

Author: Wiede, F
Although adoptive T-cell therapy has shown remarkable clinical efficacy in haematological malignancies, its success in combating solid tumours has been limited.

Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation.

Author: Coden, M
In inflamed human tissues, we often find intact eosinophilic granules, but not eosinophils themselves. Eosinophils, tissue-dwelling granulocytes with several homeostatic roles, have a surprising association with fibrinogen and tissue remodeling.

Self-Antigens Displayed on Liposomal Nanoparticles above a Threshold of Epitope Density Elicit Class-Switched Autoreactive Antibodies Independent of T Cell Help.

Author: Chen, Z
Epitope density has a profound impact on B cell responses to particulate Ags, the molecular mechanisms of which remain to be explored.

IL-18R-dependent and independent pathways account for IL-18-enhanced antitumor ability of CAR-T cells.

Author: Huang, Y
nterleukin-18 (IL-18) has been demonstrated to augment the antitumor capacity of chimeric antigen receptor-T cells (CAR-T) but the underlying mechanisms are largely unknown.

Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition

Author: Lee, J
Transcriptomic signatures designed to predict melanoma patient responses to PD-1 blockade have been reported but rarely validated.

GPA33: A Marker to Identify Stable Human Regulatory T Cells.

Author: Opstelten, R
FOXP3-expressing regulatory T (Treg) cells safeguard immunological tolerance.

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease.

Author: Losurdo, M
The critical role of neuroinflammation in favoring and accelerating the pathogenic process in Alzheimer's disease (AD) increased the need to target the cerebral innate immune cells as a potential therapeutic strategy to slow down the disease progression.

Protocol to drive human monocyte-to-macrophage polarization in vitro using tumor conditioned media.

Author: George, S

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