Research Areas

TGF-β Superfamily

Encompassing a plethora of growth, differentiation and morphogenic factors, the Transforming Growth Factor-β (TGF-β) Superfamily is comprised of signaling proteins that have been universally conserved throughout the animal kingdom and presently consists of over forty members, the likes of which include:  TGF-β isoforms, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activins, and inhibins.  Considered vital to the modulation of cell proliferation, differentiation, matrix synthesis, and apoptosis, members of the TGF-β Superfamily are fundamental to prenatal development and the postnatal growth, remodeling, and maintenance of various tissues and organs.  Noted for activating Smad signaling cascades through interactions with a conserved family of cell surface serine/threonine-specific protein kinase receptors, the complexity of TGF-β signaling has been demonstrated through the additional regulation of physiological processes by TGF-β Superfamily Ligand through non-canonical pathways, and the activation of signaling molecules other than Smad proteins.  Given the intricacies and significance associated with the activities of TGF-β Superfamily proteins, the impairment of proper signaling has been understandably connected to a variety of clinical indications, such as tumor cell growth, fibrosis, skeletal defects, and autoimmune disease.  Therefore, understanding the regulatory mechanisms that control TGF-β signaling, as well as the identification and characterization of their molecular components, have become topics of intense investigation.

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95,00 USD 2µg
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Size

95,00 USD 5µg
215,00 USD 20µg
516,00 USD 50µg
860,00 USD 100µg
1 505,00 USD 250µg
2 580,00 USD 500µg
4 300,00 USD 1mg
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Size

95,00 USD 10µg
215,00 USD 50µg
330,00 USD 100µg
577,50 USD 250µg
990,00 USD 500µg
1 650,00 USD 1mg
Looking for a custom size?
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Size

95,00 USD 2µg
215,00 USD 10µg
684,00 USD 50µg
1 140,00 USD 100µg
1 995,00 USD 250µg
3 420,00 USD 500µg
5 700,00 USD 1mg
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Size

95,00 USD 2µg
215,00 USD 10µg
684,00 USD 50µg
1 140,00 USD 100µg
1 995,00 USD 250µg
3 420,00 USD 500µg
5 700,00 USD 1mg
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Size

95,00 USD 2µg
215,00 USD 10µg
684,00 USD 50µg
1 140,00 USD 100µg
1 995,00 USD 250µg
3 420,00 USD 500µg
5 700,00 USD 1mg
Looking for a custom size?
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Size

95,00 USD 2µg
215,00 USD 10µg
516,00 USD 50µg
860,00 USD 100µg
1 505,00 USD 250µg
2 580,00 USD 500µg
4 300,00 USD 1mg
Looking for a custom size?
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Size

95,00 USD 2µg
215,00 USD 10µg
516,00 USD 50µg
860,00 USD 100µg
1 505,00 USD 250µg
2 580,00 USD 500µg
4 300,00 USD 1mg
Looking for a custom size?
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Size

95,00 USD 2µg
215,00 USD 10µg
1 140,00 USD 100µg
1 995,00 USD 250µg
3 420,00 USD 500µg
5 700,00 USD 1mg
Looking for a custom size?
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Size

95,00 USD 2µg
215,00 USD 10µg
684,00 USD 50µg
1 140,00 USD 100µg
1 995,00 USD 250µg
3 420,00 USD 500µg
5 700,00 USD 1mg
Looking for a custom size?
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Size

195,00 USD 50µg
250,00 USD 100µg
1 700,00 USD 1mg
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150,00 USD 500µg
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195,00 USD 50µg
250,00 USD 100µg
1 700,00 USD 1mg
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Size

150,00 USD 500µg
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Size

195,00 USD 50µg
250,00 USD 100µg
1 700,00 USD 1mg
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Size

195,00 USD 50µg
250,00 USD 100µg
1 700,00 USD 1mg
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Size

195,00 USD 50µg
250,00 USD 100µg
1 700,00 USD 1mg
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Size

195,00 USD 50µg
250,00 USD 100µg
1 700,00 USD 1mg
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