Research Areas

TGF-β Superfamily

Encompassing a plethora of growth, differentiation and morphogenic factors, the Transforming Growth Factor-β (TGF-β) Superfamily is comprised of signaling proteins that have been universally conserved throughout the animal kingdom and presently consists of over forty members, the likes of which include:  TGF-β isoforms, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activins, and inhibins.  Considered vital to the modulation of cell proliferation, differentiation, matrix synthesis, and apoptosis, members of the TGF-β Superfamily are fundamental to prenatal development and the postnatal growth, remodeling, and maintenance of various tissues and organs.  Noted for activating Smad signaling cascades through interactions with a conserved family of cell surface serine/threonine-specific protein kinase receptors, the complexity of TGF-β signaling has been demonstrated through the additional regulation of physiological processes by TGF-β Superfamily Ligand through non-canonical pathways, and the activation of signaling molecules other than Smad proteins.  Given the intricacies and significance associated with the activities of TGF-β Superfamily proteins, the impairment of proper signaling has been understandably connected to a variety of clinical indications, such as tumor cell growth, fibrosis, skeletal defects, and autoimmune disease.  Therefore, understanding the regulatory mechanisms that control TGF-β signaling, as well as the identification and characterization of their molecular components, have become topics of intense investigation.

Explore relevant products below.

Size

80,00 USD 5µg
195,00 USD 20µg
900,00 USD 100µg
1 800,00 USD 200µg
4 500,00 USD 500µg
7 800,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 1µg
195,00 USD 5µg
1 176,00 USD 50µg
1 960,00 USD 100µg
3 430,00 USD 250µg
5 880,00 USD 500µg
9 800,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 10µg
195,00 USD 50µg
300,00 USD 100µg
525,00 USD 250µg
900,00 USD 500µg
1 500,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 10µg
195,00 USD 50µg
300,00 USD 100µg
525,00 USD 250µg
900,00 USD 500µg
1 500,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
468,00 USD 50µg
780,00 USD 100µg
1 365,00 USD 250µg
2 340,00 USD 500µg
3 900,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 1µg
195,00 USD 5µg
720,00 USD 50µg
1 200,00 USD 100µg
4 200,00 USD 500µg
7 000,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
624,00 USD 50µg
1 040,00 USD 100µg
1 820,00 USD 250µg
3 120,00 USD 500µg
5 200,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
1 560,00 USD 100µg
2 730,00 USD 250µg
4 680,00 USD 500µg
7 800,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
1 040,00 USD 100µg
1 820,00 USD 250µg
3 120,00 USD 500µg
5 200,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 5µg
195,00 USD 20µg
780,00 USD 100µg
1 365,00 USD 250µg
2 340,00 USD 500µg
3 900,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 10µg
195,00 USD 50µg
300,00 USD 100µg
525,00 USD 250µg
900,00 USD 500µg
1 500,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
624,00 USD 50µg
1 040,00 USD 100µg
1 820,00 USD 250µg
3 120,00 USD 500µg
5 200,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
624,00 USD 50µg
1 040,00 USD 100µg
1 820,00 USD 250µg
3 120,00 USD 500µg
5 200,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
624,00 USD 50µg
1 040,00 USD 100µg
1 820,00 USD 250µg
3 120,00 USD 500µg
5 200,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
624,00 USD 50µg
1 040,00 USD 100µg
1 820,00 USD 250µg
3 120,00 USD 500µg
5 200,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
1 040,00 USD 100µg
1 820,00 USD 250µg
3 120,00 USD 500µg
5 200,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
624,00 USD 50µg
1 040,00 USD 100µg
1 820,00 USD 250µg
3 120,00 USD 500µg
5 200,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
468,00 USD 50µg
780,00 USD 100µg
1 365,00 USD 250µg
2 340,00 USD 500µg
3 900,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 2µg
195,00 USD 10µg
468,00 USD 50µg
780,00 USD 100µg
1 365,00 USD 250µg
2 340,00 USD 500µg
3 900,00 USD 1mg
Looking for a custom size?
Contact Us

Size

80,00 USD 5µg
195,00 USD 20µg
468,00 USD 50µg
780,00 USD 100µg
1 365,00 USD 250µg
2 340,00 USD 500µg
3 900,00 USD 1mg
Looking for a custom size?
Contact Us
showing 20 of 29