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Research Areas

Immune System

Representing a vast and complex network of cells, tissues, and organs, the immune system is comprised of several cell types, each having distinct and specialized functions such as engulfing bacteria, producing antibodies, and killing parasites, tumor cells and virally-infected cells, that collectively serve to protect the body from bacterial, fungal, and viral infections, as well as from the growth and dispersal of tumor cells.  Representing a duality of responsibilities, the immune system initiates the body’s quick and efficient response to alien agents, while also distinguishing these threats from the body’s healthy cells in order to avoid attacks against the host; a process known as autoimmunity. Lymphocytes and other cells from the immune system, such as macrophages and dendritic cells, produce a large array of cell signaling proteins that are collectively referred to as cytokines, which are responsible for the intercellular communications necessary for the accurate and efficient performance of both innate and adaptive immune responses.  Our understanding of the immune system has advanced significantly in recent years, and it has become evident that cytokines play a central role in the activation and regulation of the immune response.

View References for PeproTech’s products in Immune System Research:

IL-18R-dependent and independent pathways account for IL-18-enhanced antitumor ability of CAR-T cells

MUC1 as a target for CAR-T therapy in head and neck squamous cell carinoma

Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition 

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours 

Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease

GPA33: A Marker to Identify Stable Human Regulatory T Cells

DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8 + T Cell Compartment by Negatively Regulating Tonic TCR Triggering

Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition

Pembrolizumab Interferes with the Differentiation of Human FOXP3 +-Induced T Regulatory Cells, but Not with FOXP3 Stability, through Activation of mTOR

Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation

Self-Antigens Displayed on Liposomal Nanoparticles above a Threshold of Epitope Density Elicit Class-Switched Autoreactive Antibodies Independent of T Cell Help

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