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Research Areas

Stem Cells & Differentiation

The human body develops from a single diploid cell called a zygote and contains at adulthood an estimated 85 trillion cells, of which more than 150 billion turn over every day.  All of these cells originate from a tiny population of so-called “embryonic” and “adult” stem cells which uniquely possess a long-term self- renewal capacity and have the potential to differentiate into a variety of cell lineages.  “Embryonic Stem Cells (ESC)” is a term commonly used to refer to a distinct cluster of pluripotent stem cells found in the inner cell mass of mammalian blastocysts (early-stage embryos). Their primary function is to give rise to cell lineages of all three germ layers.  On the other hand, “Adult Stem Cells (ASC)” is one of several terms used to describe a diverse group of multipotent stem cells clustered in various niches throughout the body, particularly in loci with high cell turnover such as bone marrow, skin, and intestine, but also in sites with low cell turnover such as brain and pancreas. ASC, also known as somatic or tissue-specific stem cells, serve as a renewable source of specialized cells for tissue development, maintenance, and repair.  Depending upon the prevailing conditions in their microenvironment, individual stem cells express distinct cell-surface proteins and display differentiation patterns which normally suit the needs of the tissue or organ in which they reside.  Such stem-cell specialization is enabled by a battery of epigenetic regulatory factors which provide the means not only to arrest and maintain a particular stem-cell behavior, but also to modify it in response to changes in the cell’s microenvironment.

View References for PeproTech’s products in Stem Cells & Differentiation Research:

Standardized cryopreservation of pluripotent stem cells.

Author: Cohen, R
The successful exploitation of human cells for research, translational, therapeutic, and commercial purposes requires that effective and simple cryopreservation methods be applied for storage in local and master cell banks.

SPARC promotes self-renewal of limbal epithelial stem cells and ocular surface restoration through JNK and p38-MAPK signaling pathways.

Author: Zhu, J
The purpose of this study was to investigate the effects of secreted protein acidic and rich in cysteine (SPARC) on the maintenance of limbal epithelial stem cell (LESC) stemness and restoration of ocular surface.

Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures.

Author: Kelleher, J
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common form of genetic stroke and vascular dementia syndrome resulting from mutations in NOTCH3.

Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential.

Author: Lange, L
Induced pluripotent stem cells (iPSCs) offer a promising platform to model early embryonic developmental processes, to create disease models that can be evaluated by drug screens as well as proof-of-concept experiments for regenerative medicine.

p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids.

Author: Marin Navarro, A
In this study, we take advantage of human induced pluripotent stem (iPS) cell-derived neural stem cells and brain organoids to study the role of p53 during human brain development.

Growth differentiation factor 11 promotes differentiation of MSCs into endothelial-like cells for angiogenesis.

Author: Zhang, C
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family.

G-CSF Inhibits Pulmonary Fibrosis by Promoting BMSC Homing to the Lungs via SDF-1/CXCR4 Chemotaxis

Author: Zhao, F
Bone marrow mesenchymal stem cells (BMSCs) have multi-lineage differentiation potential and play an important role in tissue repair.

Grafted human pluripotent stem cell-derived cortical neurons integrate into adult human cortical neural circuitry.

Author: Grønning Hansen, M
Several neurodegenerative diseases cause loss of cortical neurons, leading to sensory, motor, and cognitive impairments.

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