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Research Areas

Neurobiology

The term neurobiology describes the scientific study of the nervous system within a purely biologic capacity, encompassing those scientific disciplines concerned with the development, molecular and cellular structure, chemistry, functionality, evolution, and pathology of the neural networks constructing the nervous system.  The nervous system, which in vertebrates is comprised of both the central and peripheral nervous systems, is a sophisticated networking of neural cells that function through the transmission of excitatory or inhibitory signaling to process information and orchestrate all bodily functions, including the capacity for motor and sensory function, cognition, and emotion.  Understanding the development and homeostasis of the nervous system, the many pathways responsible for maintaining and regulating its proper functionality, and the implications of nervous system dysfunction, remain poignant within research concerning the nervous system and neurodegenerative diseases.

View References for PeproTech’s products in Neurobiology Research:

Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases.

Author: Vivancos, V
Wnt proteins play roles in many biological processes, including axon guidance and cell migration.

Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease.

Author: El-Akabawy, G
Cell therapy is a potential therapeutic approach for several neurodegenetative disease, including Huntington Disease (HD).

iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds.

Author: Faley, S
There is a profound need for functional, biomimetic in vitro tissue constructs of the human blood-brain barrier and neurovascular unit (NVU) to model diseases and identify therapeutic interventions.

Low-level laser therapy 810-nm up-regulates macrophage secretion of neurotrophic factors via PKA-CREB and promotes neuronal axon regeneration in vitro.

Author: Zhang, J
Macrophages play key roles in the secondary injury stage of spinal cord injury (SCI).

Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical neurons.

Author: Satir, T
One of the neuropathological hallmarks of Alzheimer's disease (AD) is cerebral deposition of amyloid plaques composed of amyloid β (Aβ) peptides and the cerebrospinal fluid concentrations of those peptides are used as a biomarker for AD.



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