Recombinant Human PDGF-AB 1 ReviewsSubmit a Review Product Details Catalogue Number: 100-00AB Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one α chain and one β chain (234 total amino acids). Source: E.coli Synonyms: Platelet-Derived Growth Factor-AB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF), PCGF AA Sequence: Alpha chain: SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPTBeta chain: SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by Balb/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 26.4 kDa Accession Number: Alpha: P04085 Beta: P01127 Gene ID: Alpha: 5154 Beta: 5155 crossreactivity: Guinea Pig, Human, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer Immune System Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Meier, S Title Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation Citation Cell Death & Disease; 12(8) pg785 PubMed Id 34381018 First Author Geuder, J Title A non-invasive method to generate induced pluripotent stem cells from primate urine Citation Scientific Reports; 11(1) pg3516 PubMed Id 33568724 First Author Gillies, T E Title Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway Citation Molecular Systems Biology; 16(10) pge9518 PubMed Id 33073539 product.subtitle.productreviews Existing reviews Easy to reconstitute and store for long-term usage The item came fast, it's easy to reconstitute and there's enough options to indicate storage and usage at given temperatures. It's worked well in a variety of assays and I will continue to use this product. From: Vikram | Date: 22/07/2020 × Easy to reconstitute and store for long-term usage The item came fast, it's easy to reconstitute and there's enough options to indicate storage and usage at given temperatures. It's worked well in a variety of assays and I will continue to use this product. From: Vikram | Date: 22/07/2020 Close
