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Recombinant Murine Resistin

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Product Details

Catalogue Number: 450-28
Description:
Recombinant Murine Resistin

Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The four known members of this family, resistin, RELMα, RELMβ, and RELMγ, share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that resistin expression is severely suppressed in obesity, and that it may act as a feedback regulator of Adipogenesis. Recombinant Murine Resistin is a 20.2 kDa, disulfide-linked, homodimeric protein composed of two identical 94 amino acid chains linked by a single disulfide bond.

Source: E.coli

Synonyms: FIZZ3, Adipose tissue-specific secretory factor, ADSF

AA Sequence (monomer): SSMPLCPIDE AIDKKIKQDF NSLFPNAIKN IGLNCWTVSS RGKLASCPEG TAVLSCSCGS ACGSWDIREE KVCHCQCARI DWTAARCCKL QVAS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 20.2 kDa

Accession Number: Q99P87

Gene ID: 57264

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Junkin, K A
Title
Resistin acutely impairs insulin-stimulated glucose transport in rodent muscle in the presence, but not absence, of palmitate.
Citation
American journal of physiology. Regulatory, integrative and comparative physiology; 296(4) pgR944-51
PubMed Id
First Author
Bokarewa, M
Title
Resistin, an adipokine with potent proinflammatory properties.
Citation
Journal of immunology (Baltimore, Md. : 1950); 174(9) pg5789-95
PubMed Id
First Author
Ort, T
Title
Recombinant human FIZZ3/resistin stimulates lipolysis in cultured human adipocytes, mouse adipose explants, and normal mice.
Citation
Endocrinology; 146(5) pg2200-9
PubMed Id