Recombinant Human BMP-7 0 ReviewsSubmit a Review Product Details Catalogue Number: 120-03P Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of an appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant Human BMP-7 is a homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 315 to 431 of the full-length BMP-7 precursor. Recombinant Human BMP-7 has a calculated molecular weight of 26.4 kDa; however, due to glycosylation, the BMP-7 homodimer migrates at an apparent molecular weight of approximately 25-35 kDa by SDS-PAGE analysis under non-reducing conditions. Source: CHO cells Synonyms: Bone Morphogenetic Protein-7, Osteogenic Protein-1 (OP-1) AA Sequence (monomer): MANVAENSSS DQRQACKKHE LYVSFRDLGW QDWIIAPEGY AAYYCEGECA FPLNSYMNAT NHAIVQTLVH FINPETVPKP CCAPTQLNAI SVLYFDDSSN VILKKYRNMV VRACGCH Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 μg/ml. Calculated Molecular Weight: 26.4 kDa Accession Number: P18075 Gene ID: 655 Note: 100μg is the largest vial size for this product. Larger sizes supplied as multiple 100μg vials. crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cell Culture Immune System Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Guo, D Title Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. Citation The Journal of Experimental Medicine; 218(9) PubMed Id 34254999 First Author Jacob, F Title Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium. Citation Cell Stem Cell; 27(6) pg937-950.e9 PubMed Id 33010822 First Author Rore, H Title Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells Citation Communications Biology; 4(1) pg802 PubMed Id 34183774