Growth Factors & Cytokines

Recombinant Rat IL-1β

Product Details

Catalog Number: 400-01B
Description:

IL-1b is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells.  Both IL-1a and IL-1b bind to the same receptor and have similar, if not identical, biological properties.  These cytokines have a broad range of activities, including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and, the release of prostaglandin and collagenase from synovial cells.  However, whereas IL-1b is a secreted cytokine, IL-1a is predominantly a cell-associated cytokine.  Recombinant Rat IL-1b is a 17.4 kDa protein containing 153 amino acid residues.

Source: E.coli

Synonyms: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

AA Sequence: MVPIRQLHCR LRDEQQKCLV LSDPCELKAL HLNGQNISQQ VVFSMSFVQG ETSNDKIPVA LGLKGLNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKTK VEFESAQFPN WYISTSQAEH RPVFLGNSNG RDIVDFTMEP VSS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

Cross Reactivity:
Mouse, Rat
Research Interest

Country Of Origin: USA

Research Use Only: Not for use in diagnostic or therapeutic procedures.