RUO Cytokines

RUO Cytokines

PeproTech's Product Catalog has grown to encompass an extensive selection of recombinant proteins primarily, but not exclusively, of human, murine, and rat origin. The subcategories of PeproTech’s protein products have expanded to include Growth Factors and Cytokines, Chemokines, Neurotrophins, Proteases, Animal-Free Recombinant Proteins, and Other Miscellaneous Proteins that do not fall under one of the umbrellas of these other groupings.

Size

80.00 USD 100µg
195.00 USD 500µg
250.00 USD 1mg
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Recombinant Aeromonas Aminopeptidase

SKU: 100-10

Proteases (also called Proteolytic Enzymes, Peptidases, or Proteinases) are enzymes that hydrolyze the amide bonds within proteins or peptides. Most proteases act in a specific manner, hydrolyzing bonds at, or adjacent to specific residues, or a specific sequence of residues contained within the substrate protein or peptide. Proteases play an important role in most diseases and biological processes, including prenatal and postnatal development, reproduction, signal transduction, the immune response, various autoimmune and degenerative diseases, and cancer. They are also an important research tool, frequently used in the analysis and production of proteins.  Recombinant Aeromonas Aminopeptidase is a 31.4 kDa protein containing 291 amino acid residues.

Source: E.coli

Synonyms: None

AA Sequence: MPPITQQATV TAWLPQVDAS QITGTISSLE SFTNRFYTTT SGAQASDWIA SEWQALSASL PNASVKQVSH SGYNQKSVVM TITGSEAPDE WIVIGGHLDS TIGSHTNEQS VAPGADDDASGIAAVTEVIR VLSENNFQPK RSIAFMAYAA EEVGLRGSQD LANQYKSEGK NVVSALQLDM TNYKGSAQDV VFITDYTDSN FTQYLTQLMD EYLPSLTYGF DTCGYACSDH ASWHNAGYPAAMPFESKFND YNPRIHTTQD TLANSDPTGS HAKKFTQLGL AYAIEMGSAT G

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Sequentially cleaves N-terminal amino acids except E, D, and X-P.

Note:

1mg will be provided as 2x500μg.

Size

80.00 USD 2µg
195.00 USD 10µg
650.00 USD 50µg
1,200.00 USD 100µg
2,275.00 USD 250µg
3,900.00 USD 500µg
6,500.00 USD 1mg
Looking for a custom size?
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Recombinant Human/Murine/Rat Activin A (Insect derived)

SKU: 120-14

Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.  Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.  The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.  Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B).  Activins are homodimers or heterodimers of different β subunits.  They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand.  Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

Source: Hi-5 Insect cells

Synonyms: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein

AA Sequence (monomer): GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Note:

1mg will be provided as 2x500μg.

Size

80.00 USD 2µg
195.00 USD 10µg
468.00 USD 50µg
780.00 USD 100µg
1,365.00 USD 250µg
2,340.00 USD 500µg
3,900.00 USD 1mg
Looking for a custom size?
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Recombinant Human/Murine/Rat Activin A (E.coli derived)

SKU: 120-14E

Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.  Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.  The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.  Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B).  Activins are homodimers or heterodimers of different β subunits.  They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand.  Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

Source: E.coli

Synonyms: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein

AA Sequence (monomer): GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS

Purity: Greater than 97% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Note:

1mg will be provided as 2x500μg.

Size

95.00 USD 2µg
215.00 USD 10µg
516.00 USD 50µg
860.00 USD 100µg
1,505.00 USD 250µg
2,580.00 USD 500µg
4,300.00 USD 1mg
Looking for a custom size?
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Animal-Free Recombinant Human/Murine/Rat Activin A (E.coli derived)

SKU: AF-120-14E

Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.  Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.  The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.  Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B).  Activins are homodimers or heterodimers of different β subunits.  They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand.  Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein

AA Sequence (monomer): GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS

Purity: Greater than 97% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Note:

1mg will be provided as 2x500μg.

Size

80.00 USD 2µg
195.00 USD 10µg
624.00 USD 50µg
1,040.00 USD 100µg
1,820.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
Looking for a custom size?
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Recombinant Human/Murine/Rat Activin A (CHO derived)

SKU: 120-14P

Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

Source: CHO cells

Synonyms: Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein

AA Sequence (monomer): GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Note:

1mg will be provided as 2x500μg.

Size

80.00 USD 1µg
195.00 USD 5µg
1,176.00 USD 50µg
1,960.00 USD 100µg
3,430.00 USD 250µg
5,880.00 USD 500µg
9,800.00 USD 1mg
Looking for a custom size?
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Recombinant Human Activin B

SKU: 120-15

Activin B is a TGF-β family member that exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands.  Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II).  Activins are homodimers or heterodimers of different β subunits.  They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand.  Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.

Source: Hi-5 Insect cells

Synonyms: Activin beta-B, Inhibin beta-2

AA Sequence (monomer): GLECDGRTNL CCRQQFFIDF RLIGWNDWII APTGYYGNYC EGSCPAYLAG VPGSASSFHT AVVNQYRMRG LNPGTVNSCC IPTKLSTMSM LYFDDEYNIV KRDVPNMIVE ECGCA

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Note:

100μg is the largest vial size for this product.
Larger sizes supplied as multiple 50μg and/or 100μg vials.

Size

80.00 USD 5µg
195.00 USD 25µg
700.00 USD 100µg
1,750.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
Looking for a custom size?
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Recombinant Human Adiponectin

SKU: 450-24

Adiponectin is an adipose-derived secreted protein containing 226 amino acid residues. It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein. The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes. Disruption of adiponectin in mice causes insulin resistance and neointimal formation. Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity. The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing amino acids Glu-19 to Asn-244 of the adiponectin precursor protein fused to an N-terminal histidine tag. Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 35.0 kDa by SDS PAGE analysis under reducing conditions.  The calculated molecular weight of Recombinant Human Adiponectin is 25.9 kDa.

Source: Hi-5 Insect cells

Synonyms: Acrp-30, GBP-28, APM-1, Gelatin-binding protein, AdipoQ

AA Sequence: RGHHHHHHHH ETTTQGPGVL LPLPKGACTG WMAGIPGHPG HNGAPGRDGR DGTPGEKGEK GDPGLIGPKG DIGETGVPGA EGPRGFPGIQ GRKGEPGEGA YVYRSAFSVG LETYVTIPNM PIRFTKIFYN QQNHYDGSTG KFHCNIPGLY YFAYHITVYM KDVKVSLFKK DKAMLFTYDQ YQENNVDQAS GSVLLHLEVG DQVWLQVYGE GERNGLYADN DNDSTFTGFL LYHDTN

Purity: Greater than 97% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cytotoxic assay using M1 cells. The ED50 for this effect is 3.0-6.0 μg/ml.

Note:

1mg will be provided as 2x500μg.

Size

80.00 USD 5µg
195.00 USD 25µg
360.00 USD 50µg
700.00 USD 100µg
1,750.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
Looking for a custom size?
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Recombinant Murine Adiponectin

SKU: 315-26

Adiponectin is an adipose-derived secreted protein containing 236 amino acid residues.  It is relatively abundant in humans and rodents, accounting for about 0.01% of total plasma protein.  The circulating levels of adiponectin are decreased under conditions of obesity, insulin resistance, and type II diabetes.  Disruption of adiponectin in mice causes insulin resistance and neointimal formation.  Conversely, administration of recombinant adiponectin suppresses hepatic glucose production, and reverses insulin resistance associated with both lipoatrophy and obesity.  The protective role of adiponectin is attributed to its anti-inflammatory properties (e.g. ability to suppress expression of TNF-α and class A scavenger receptor in macrophages). Recombinant adiponectin is a multimeric glycoprotein containing amino acids Val-21 to Asn-247 of the adiponectin precursor protein fused to an N-terminal histidine tag.  Monomeric glycosylated adiponectin migrates at an apparent molecular weight of approximately 35.0 kDa by SDS PAGE analysis under reducing conditions.  The calculated molecular weight of Recombinant Murine Adiponectin is 25.8 kDa.

Source: Hi-5 Insect cells

Synonyms: Acrp-30, GBP-28, APM-1

AA Sequence: RGHHHHHHHH VTTTEELAPA LVPPPKGTCA GWMAGIPGHP GHNGTPGRDG RDGTPGEKGE KGDAGLLGPK GETGDVGMTG AEGPRGFPGT PGRKGEPGEA AYVYRSAFSV GLETRVTVPN VPIRFTKIFY NQQNHYDGST GKFYCNIPGL YYFSYHITVY MKDVKVSLFK KDKAVLFTYD QYQEKNVDQA SGSVLLHLEV GDQVWLQVYG DGDHNGLYAD NVNDSTFTGF LLYHDTN

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cytotoxic assay using M1 cells.  The ED50 for this effect is 4.0-6.0 μg/ml.

Size

80.00 USD 5µg
195.00 USD 20µg
850.00 USD 100µg
1,820.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
Looking for a custom size?
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Recombinant Human AITRL

SKU: 310-22

AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177 amino acids, including a 28 amino acid cytoplasmic region, a 21 amino acid transmembrane domain and a 128 amino acid extracellular domain. Recombinant Human soluble AITRL is a 14.4 kDa protein, containing 127 amino acid residues corresponding to the extracellular domain of AITRL.

Source: E.coli

Synonyms: Activation-induced TNFR member Ligand, TNFSF18, GITRL, TL-6

AA Sequence: METAKEPCMA KFGPLPSKWQ MASSEPPCVN KVSDWKLEIL QNGLYLIYGQ VAPNANYNDV APFEVRLYKN KDMIQTLTNK SKIQNVGGTY ELHVGDTIDL IFNSEHQVLK NNTYWGIILL ANPQFIS

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1.0-10.0 ng/ml.
Please Note: Results may vary with PBMC donors.

Size

80.00 USD 10µg
195.00 USD 50µg
300.00 USD 100µg
525.00 USD 250µg
900.00 USD 500µg
1,500.00 USD 1mg
Looking for a custom size?
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Recombinant Human Amphiregulin

SKU: 100-55B

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Human Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues.

Source: E.coli

Synonyms: AR, AREG, Colorectum cell-derived growth factor (CRDGF)

AA Sequence: SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.

Size

80.00 USD 5µg
195.00 USD 20µg
850.00 USD 100µg
1,820.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
Looking for a custom size?
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Recombinant Human ANG-1

SKU: 130-06

Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a tyrosine-kinase receptor expressed primarily on vascular endothelial cells and early hematopoietic cells.  Ang-1/Tie-2 signaling promotes angiogenesis during the development, remodeling, and repair of the vascular system.  Transgenic mice lacking expression of either Ang-1 or Tie-2 fail to develop a fully functional cardiovascular system and die before birth.  Postnatally, the angiogenic activity of Ang-1/Tie-2 is required during normal tissue repair and remodeling of the female endometrium in the menstrual cycle.  Ang-1/Tie-2 signaling appears to be regulated by Angiopoietin-2 (Ang-2), a natural antagonist for Tie-2 that exerts its effects through an internal autocrine loop mechanism. In addition to suppressing endothelial cell activation by inhibiting the expression of adhesion and inflammatory molecules, Ang-1 enhances endothelial cell survival and capillary morphogenesis, and lessens capillary permeability.  As such, Ang-1 has potential to become an effective therapeutic agent for treating various endothelium disorders, including several severe human pulmonary diseases. The efficacy of cell-based Ang-1 gene therapy for acute lung injury (ALI) has recently been studied in a rat model of ALI.  The results of this study show that such therapy can markedly improve lung condition and suggest that Ang-1 therapy may represent a potential new strategy for the treatment and/or prevention of acute respiratory distress injury (ARDI), a significant cause of morbidity and mortality in critically ill patients.  Recombinant human ANG-1, derived from HeLa cells, is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows N-terminal sequences starting with Ser-20 and with Asp-70 of the 498 amino acid precursor protein.  The calculated molecular weight of Recombinant Human ANG-1 is 56.3 kDa.

Source: HeLa cells

Synonyms: Angiopoietin-1, ANGPT1, KIAA0003

AA Sequence: SNQRRSPENS GRRYNRIQHG QCAYTFILPE HDGNCRESTT DQYNTNALQR DAPHVEPDFS SQKLQHLEHV MENYTQWLQK LENYIVENMK SEMAQIQQNA VQNHTATMLE IGTSLLSQTA EQTRKLTDVE TQVLNQTSRL EIQLLENSLS TYKLEKQLLQ QTNEILKIHE KNSLLEHKIL EMEGKHKEEL DTLKEEKENL QGLVTRQTYI IQELEKQLNR ATTNNSVLQK QQLELMDTVH NLVNLCTKEG VLLKGGKREE EKPFRDCADV YQAGFNKSGI YTIYINNMPE PKKVFCNMDV NGGGWTVIQH REDGSLDFQR GWKEYKMGFG NPSGEYWLGN EFIFAITSQR QYMLRIELMD WEGNRAYSQY DRFHIGNEKQ NYRLYLKGHT GTAGKQSSLI LHGADFSTKD ADNDNCMCKC ALMLTGGWWF DACGPSNLNG MFYTAGQNHG KLNGIKWHYF KGPSYSLRST TMMIRPLDFH HHHHH

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC).

Note:

100μg is the largest vial size for this product.
Larger sizes supplied as multiple 50μg and/or 100μg vials.

Size

80.00 USD 5µg
195.00 USD 20µg
850.00 USD 100µg
1,820.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
Looking for a custom size?
Contact Us

Recombinant Human ANG-2

SKU: 130-07

ANG-2 binds to the endothelial cell specific receptor Tie-2, but, in contrast to ANG-1, does not induce tyrosine phosphorylation.  Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and, depending on the physiological and biochemical environment, can act either as an agonist or antagonist of Tie-2 induced angiogenesis.  The signaling interactions of ANG-1, ANG-2 and Tie-2, along with less characterized ANG-3 and ANG-4, are required for embryonic and adult angiogenesis.  Physiologically, ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels.  Mature human ANG-2 is a secreted protein containing 480 amino acid residues.  ANG-2 is composed of an alpha-helix-rich “coiled coil” N-terminal domain and fibrinogen-like C-terminal domain.  ANG-2 exists predominantly in the form of a disulfide-linked dimer.  Recombinant Human ANG-2 is a C-terminal histidine-tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows an N-terminal sequence starting with residue 68 (D) of the ANG-2 precursor protein.  The calculated molecular weight of Recombinant Human ANG-2 is 50.1 kDa.

Source: CHO cells

Synonyms: Angiopoietin-2, ANGPT2

AA Sequence: DAPLEYDDSV QRLQVLENIM ENNTQWLMKL ENYIQDNMKK EMVEIQQNAV QNQTAVMIEI GTNLLNQTAE QTRKLTDVEA QVLNQTTRLE LQLLEHSLST NKLEKQILDQ TSEINKLQDK NSFLEKKVLA MEDKHIIQLQ SIKEEKDQLQ VLVSKQNSII EELEKKIVTA TVNNSVLQKQ QHDLMETVNN LLTMMSTSNS AKDPTVAKEE QISFRDCAEV FKSGHTTNGI YTLTFPNSTE EIKAYCDMEA GGGGWTIIQR REDGSVDFQR TWKEYKVGFG NPSGEYWLGN EFVSQLTNQQ RYVLKIHLKD WEGNEAYSLY EHFYLSSEEL NYRIHLKGLT GTAGKISSIS QPGNDFSTKD GDNDKCICKC SQMLTGGWWF DACGPSNLNG MYYPQRQNTN KFNGIKWYYW KGSGYSLKAT TMMIRPADFH HHHHH

Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate tubulogenesis in HUVEC cells using a concentration of 0.2μg/ml

Size

80.00 USD 10µg
195.00 USD 50µg
300.00 USD 100µg
525.00 USD 250µg
900.00 USD 500µg
1,500.00 USD 1mg
Looking for a custom size?
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Recombinant Human ANGPTL-3

SKU: 130-18

ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. It is primarily expressed in the liver and can exert activities related to both angiogenesis and lipid metabolism. ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase (EL), which has the effect of increasing plasma levels of triglycerides and HDL associated cholesterol. The fibrinogen like portion of the ANGPTL-3 protein can bind alpha-5/beta-3 integrins leading to endothelial cell adhesion and migration.  Recombinant human ANGPTL-3 is a glycoprotein that migrates by SDS-PAGE analysis at an apparent molecular weight of 62 kDa, and contains 452 amino acid residues including a C-terminal His tag.

Source: CHO cells

Synonyms: Angiopoietin-like protein 3, ANG-5, ANGPT5

AA Sequence: SRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVHKTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL QVKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQPETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KEIENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPAEC TTIYNRGEHT SGMYAIRPSN SQVFHVYCDV ISGSPWTLIQ HRIDGSQNFN ETWENYKYGF GRLDGEFWLG LEKIYSIVKQ SNYVLRIELE DWKDNKHYIE YSFYLGNHET NYTLHLVAIT GNVPNAIPEN KDLVFSTWDH KAKGHFNCPE GYSGGWWWHD ECGENNLNGK YNKPRAKSKP ERRRGLSWKS QNGRLYSIKS TKMLIHPTDS ESFEHHHHHH HH

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its binding ability to recombinant αvβ3 integrin in a functional ELISA. 

Size

80.00 USD 5µg
195.00 USD 20µg
850.00 USD 100µg
1,820.00 USD 250µg
3,120.00 USD 500µg
5,200.00 USD 1mg
Looking for a custom size?
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Recombinant Human ANGPTL-7

SKU: 130-22

Angiopoietin-like 7 (ANGPTL-7), or Cornea-Derived Transcript 6 (CDT6), is a member of the angiopoietin family of structurally related proteins, characterized by a coiled N-terminal domain and a C-terminal fibrinogen like domain. While ANGPTL-7 shares the structural features of the angiopoietin family, it plays a critical role in blocking the vascular endothelial Tie2 receptor to which other family members bind. Through the blocking of the Tie2 receptor, ANGPTL-7 does not act as a “true” angiopoietin, but rather as a morphogen that contributes to the avascularity and transparency of the cornea during both embryo and adult development. Human ANGPTL-7 is expressed at high levels in the avascular corneal stromal layer, a site of pathological angiogenesis normally devoid of blood vessels, suggesting that the protein acts as a negative regulator of angiogenesis in a manner similar to that of angiopoietin-1 and angiopoietin-2. In mouse xenograft models, ANGPTL-7overexpression has been shown to lead to increased extracellular matrix components typical of a mature corneal stromal layer, as well as the reduction of tumor growth and aberrant blood vessel formation. Overexpression in human melanoma models shows a contradictory, up-regulation of endostatin, an endogenous angiostatic factor, in comparison to the down-regulation observed in mouse models. Recombinant Human ANGPTL-7 is a glycoprotein that migrates by SDS-PAGE analysis at an apparent molecular weight of 40- 50 kDa under reduced conditions, and contains 328 amino acid residues including a C-terminal His-tag. The calculated molecular weight of Recombinant Human ANGPTL-7 is 38.2 kDa.

Source: Hi-5 Insect cells

Synonyms: Angiopoietin-related protein 7, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein, CDT6

AA Sequence: QKLSKHKTPA QPQLKAANCC EEVKELKAQV ANLSSLLSEL NKKQERDWVS VVMQVMELES NSKRMESRLT DAESKYSEMN NQIDIMQLQA AQTVTQTSAD AIYDCSSLYQ KNYRISGVYK LPPDDFLGSP ELEVFCDMET SGGGWTIIQR RKSGLVSFYR DWKQYKQGFG SIRGDFWLGN EHIHRLSRQP TRLRVEMEDW EGNLRYAEYS HFVLGNELNS YRLFLGNYTG NVGNDALQYH NNTAFSTKDK DNDNCLDKCA QLRKGGYWYN CCTDSNLNGV YYRLGEHNKH LDGITWYGWH GSTYSLKRVE MKIRPEDFKP HHHHHHHH

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its binding ability to recombinant αvβ3 integrin in a functional ELISA.

Catalog Number: 350-11
Subcategory: Other Proteins

Size

80.00 USD 20µg
195.00 USD 100µg
385.00 USD 250µg
660.00 USD 500µg
1,100.00 USD 1mg
Looking for a custom size?
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Recombinant Human ApoA-I

SKU: 350-11

ApoA-I is a 29.0 kDa protein produced in the liver and intestine, and secreted as the predominant constituent of nascent high density lipoprotein (HDL) particle.  ApoA-I, which is found exclusively in HDL, has a unique ability to capture and solubilize free cholesterol.  This ApoA-I ability enables HDL to remove excess peripheral cholesterol, and return it to the liver for recycling and excretion.  This process, called reverse cholesterol transport, is thought to inhibit atherogenesis.  For this reason, HDL is also known as the “good cholesterol.”  The therapeutic potential of ApoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of ApoA-I (called ApoA-I Milano).  The availability of recombinant normal ApoA-I should facilitate further investigation into the potential usefulness of ApoA-I in preventing atherosclerotic vascular diseases.  Recombinant Human ApoA-I is a 28.2 kDa protein of 244 amino acid residues.

Source: E.coli

Synonyms: Apolipoprotein A-I

AA Sequence: MDEPPQSPWD RVKDLATVYV DVLKDSGRDY VSQFEGSALG KQLNLKLLDN WDSVTSTFSK LREQLGPVTQ EFWDNLEKET EGLRQEMSKD LEEVKAKVQP YLDDFQKKWQ EEMELYRQKV EPLRAELQEG ARQKLHELQE KLSPLGEEMR DRARAHVDAL RTHLAPYSDE LRQRLAARLE ALKENGGARL AEYHAKATEH LSTLSEKAKP ALEDLRQGLL PVLESFKVSF LSALEEYTKK LNTQ

Purity: Greater than 97% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Catalog Number: 350-12
Subcategory: Other Proteins

Size

80.00 USD 100µg
195.00 USD 500µg
350.00 USD 1mg
Looking for a custom size?
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Recombinant Human ApoE2

SKU: 350-12

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism.  In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism.  Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ.  ApoE is an important constituent of all plasma lipoproteins.  Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism.  It also binds with the LDL receptor (apo B/E).  Defects in ApoE are a cause of hyperlipoproteinemia type III.  ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution.  Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity.  E2 allele carriers had significantly lower levels of total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol, as well as increased ApoE levels.  Recombinant Human ApoE2 is a 34.3 kDa protein containing 300 amino acid residues.

Source: E.coli

Synonyms: Apolipoprotein E2

AA Sequence: MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKCL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH

Purity: Greater than 90% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Note:

1mg will be provided as 2x500μg.

Catalog Number: 350-02
Subcategory: Other Proteins

Size

80.00 USD 100µg
195.00 USD 500µg
350.00 USD 1mg
Looking for a custom size?
Contact Us

Recombinant Human ApoE3

SKU: 350-02

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism.  In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism.  Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ.  ApoE is an important constituent of all plasma lipoproteins.  Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism.  It also binds with the LDL receptor (apo B/E).  Defects in ApoE are a cause of hyperlipoproteinemia type III.  ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution.  E3 is the most common isoform and is present in 40-90% of the population.  Recombinant Human ApoE3 is a 34.0 kDa protein containing 300 amino acid residues.

Source: E.coli

Synonyms: Apoprotein E3

AA Sequence: MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH

Purity: Greater than 90% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Note:

1mg will be provided as 2x500μg.

Catalog Number: 350-04
Subcategory: Other Proteins

Size

80.00 USD 100µg
195.00 USD 500µg
350.00 USD 1mg
Looking for a custom size?
Contact Us

Recombinant Human ApoE4

SKU: 350-04

ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism.  In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism.  Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ.  ApoE is an important constituent of all plasma lipoproteins.  Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism.  It also binds with the LDL receptor (apo B/E).  Defects in ApoE are a cause of hyperlipoproteinemia type III.  ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution.  Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer’s disease.  Recombinant Human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

Source: E.coli

Synonyms: Apolipoprotein E4

AA Sequence: MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVRGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH

Purity: Greater than 90% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Note:

1mg will be provided as 2x500μg.

Catalog Number: 300-13
Subcategory: Other Proteins

Size

80.00 USD 10µg
195.00 USD 50µg
215.00 USD 100µg
280.00 USD 250µg
480.00 USD 500µg
800.00 USD 1mg
Looking for a custom size?
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Recombinant Human Apo-SAA

SKU: 300-13

Human Apo-SAA is a 104 amino acid polypeptide that circulates primarily in association with high-density lipoproteins (HDL). The level of Apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apolipoprotein. The human SAA gene codes for a 122 amino acid polypeptide, which contains an 18 amino acid N-terminal signal sequence. Recombinant Apo-SAA is a consensus SAA molecule corresponding to human Apo-SAA1α, except for the presence of an N-terminal methionine, the substitution of asparagine for aspartic acid at position 60, and arginine for histidine at position 71 (the latter two substituted residues are present in Apo-SAA2β).  The calculated molecular weight of Recombinant Human Apo-SAA is 11.7 kDa.

Source: E.coli

Synonyms: None

AA Sequence: MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGP GGVWAAEAIS NARENIQRFF GRGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Tested by its ability to down-regulate lipid biosynthesis in aortic smooth muscle cells. The effective concentration was found to be 4 μM.*

* Schreiber, BM. et al. Biochem J. 1999 Nov 15; 344 Pt 1:7-13

Catalog Number: 300-53
Subcategory: Other Proteins

Size

80.00 USD 10µg
195.00 USD 50µg
280.00 USD 100µg
490.00 USD 250µg
840.00 USD 500µg
1,400.00 USD 1mg
Looking for a custom size?
Contact Us

Recombinant Human Apo-SAA1

SKU: 300-53

Serum amyloid A proteins (SAA) represents a family of apolipoproteins that circulates in association with high-density lipoproteins (HDL). The level of Apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apolipoprotein. The human SAA gene codes for a 122 amino acid nonglycosylated polypeptide, which contains an 18 amino acid N-terminal sequence. Recombinant Human Apo-SAA1 is an 11.7 kDa protein containing 105 amino acid residues.

Source: E.coli

Synonyms: None

AA Sequence: MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGP GGVWAAEAIS DARENIQRFF GHGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY

Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.

Note:

1mg will be provided as 2x500μg.

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